Predicting pediatric esophageal wall thickness: An EUS study
| العنوان: | Predicting pediatric esophageal wall thickness: An EUS study |
|---|---|
| المؤلفون: | Rachel Sklar, Jeremy Weedon, Evan Grossman, Simon S Rabinowitz, Raavi Gupta, Lisa Feng, Frank G. Gress, Steven M Schwarz, Bo Lin, Nonyelum Ebigbo |
| المصدر: | Endoscopic Ultrasound |
| بيانات النشر: | Wolters Kluwer - Medknow, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | esophagus, Hepatology, Endoscope, pediatrics, business.industry, Esophageal wall, Ultrasound, Gastroenterology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Submucosa, medicine, 030211 gastroenterology & hepatology, Radiology, Nuclear Medicine and imaging, Original Article, Esophagus, business, Nuclear medicine, Eosinophilic esophagitis, EUS, Distal esophagus |
| الوصف: | Background and Objective: EUS has been shown in two small series to be capable of documenting increases in the total esophageal wall thickness (TWT) in children and adults with eosinophilic esophagitis (EoE). To apply EUS-derived TWT in clinical situations or in scientific investigations in pediatric EoE, measurements of esophageal TWT in children of differing ages and heights are required. Materials and Methods: Thirty patients (18M: 12F, 7 months to 20 years and 10 months) with a history of esophageal symptoms, but no endoscopic or histologic criteria of EoE were studied using a through the scope 20 MHZ Olympus Ultrasound miniprobe UM-3R (Olympus America, Center Valley Pa 18034) through a GIF Q180 or 160 (Olympus) standard pediatric upper endoscope. The mucosa, the mucosa plus submucosa, and the TWT were measured in the mid- and distal esophagus immediately before taking diagnostic biopsies. Results: Measurements from both sites showed a statistically significant increase in TWT as a function of age (P < 0.001) and height (P < 0.001), as did the individual layers. The width of the mucosa and the submucosa were equivalent and together, they contributed more than half of the entire TWT. There were no significant differences between the means of the mid- and distal esophageal measurements. A multiple regression equation that can predict TWT based on age, with 95% confidence limits, is presented. Conclusions: EUS has demonstrated that esophageal TWT in a cohort of control children correlates with height and with age and has provided insights into the organization of the esophageal wall. Esophageal TWT values obtained by EUS can now be interpreted to recognize esophageal wall thickening throughout childhood. |
| اللغة: | English |
| تدمد: | 2226-7190 2303-9027 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca55640e8b0135afe713701fd22e1100 http://europepmc.org/articles/PMC7529003 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ca55640e8b0135afe713701fd22e1100 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22267190 23039027 |
|---|