Genomic analysis of primary and recurrent gliomas reveals clinical outcome related molecular features
| العنوان: | Genomic analysis of primary and recurrent gliomas reveals clinical outcome related molecular features |
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| المؤلفون: | Jun Wu, Longbo Zhang, Tianxiang Huang, Shannon Teaw, Xi Li, Fenghua Chen, Xuefeng Xia, Qianying Yuan, Lianpeng Chang, Lei Huo, Zhixiong Liu, Jin Li, Yujie Ma, Ying Wang, Xinqi Fang, Wenjie Zheng, Tao Song, Zhiqiang Liu, Xuan Gong |
| المصدر: | Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Oncology, Adult, Male, medicine.medical_specialty, IDH1, DNA Copy Number Variations, lcsh:Medicine, Recurrent Glioma, Article, Disease-Free Survival, Prognostic markers, Text mining, CDKN2A, Internal medicine, medicine, Biomarkers, Tumor, Humans, Copy-number variation, lcsh:Science, Grading (tumors), Survival analysis, Multidisciplinary, business.industry, lcsh:R, High-Throughput Nucleotide Sequencing, Glioma, Middle Aged, Neoplasm Proteins, CNS cancer, Survival Rate, Biomarker (medicine), Female, lcsh:Q, Neoplasm Recurrence, Local, business |
| الوصف: | Tremendous efforts have been made to explore biomarkers for classification and grading on gliomas. The goal of this study was to identify more molecular features that are associated with clinical outcomes by comparing the genomic profiles of primary and recurrent gliomas and determine potential recurrence leading factors that are significantly enriched in relapse tumors. Hybrid capture based next generation sequencing (NGS) analysis was performed on 64 primary and 17 recurrent glioma biopsies. Copy number variation (CNV) was more frequent in recurrent tumors and CDKN2A/B loss was significantly enriched. In addition, overall mutations in cell cycle pathway are more common in relapse tumors. The patterns of gene sets, including IDH1/TERT and IDH1/TP53 exhibited significant difference between the groups. Survival analysis uncovered the worse disease-free survival (DFS) and overall survival (OS) associated with altered copy number and excessive activation of CELL CYCLE pathway. High Tumor Mutation Burden (TMB) was also a biomarker with great potential for poor prognosis. The assessment of genomic characteristics in primary versus recurrent gliomas aids the discovery of potential predictive biomarkers. The prognostic value of TMB in gliomas was raised for the first time. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5f7ebf9ed1020d9037b50e01ef497a http://link.springer.com/article/10.1038/s41598-019-52515-9 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ca5f7ebf9ed1020d9037b50e01ef497a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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