A Not-So-Ancient Grease History: Click Chemistry and Protein Lipid Modifications
| العنوان: | A Not-So-Ancient Grease History: Click Chemistry and Protein Lipid Modifications |
|---|---|
| المؤلفون: | Keun-Young Park, Kiall F. Suazo, Mark D. Distefano |
| المصدر: | Chem Rev |
| بيانات النشر: | American Chemical Society (ACS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | chemistry.chemical_classification, 010405 organic chemistry, Protein immobilization, Proteins, General Chemistry, Lipid Metabolism, 010402 general chemistry, Thioester, Lipids, 01 natural sciences, Article, 0104 chemical sciences, chemistry.chemical_compound, Fluorescent labelling, Enzyme, Thioether, chemistry, Biochemistry, Click chemistry, Animals, Humans, Click Chemistry, lipids (amino acids, peptides, and proteins), Lipid modification, Protein Processing, Post-Translational |
| الوصف: | Protein lipid modification involves the attachment of hydrophobic groups to proteins via ester, thioester, amide, or thioether linkages. In this review, the specific click chemical reactions that have been employed to study protein lipid modification and their use for specific labeling applications are first described. This is followed by an introduction to the different types of protein lipid modifications that occur in biology. Next, the roles of click chemistry in elucidating specific biological features including the identification of lipid-modified proteins, studies of their regulation, and their role in diseases are presented. A description of the use of protein-lipid modifying enzymes for specific labeling applications including protein immobilization, fluorescent labeling, nanostructure assembly, and the construction of protein-drug conjugates is presented next. Concluding remarks and future directions are presented in the final section. |
| تدمد: | 1520-6890 0009-2665 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8ff45505ebe001b5b7cd106f7fd8b6 https://doi.org/10.1021/acs.chemrev.0c01108 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ca8ff45505ebe001b5b7cd106f7fd8b6 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15206890 00092665 |
|---|