Development of asolectin-based liposomal formulation for controlled and targeted delivery of erlotinib as a model drug for EGFR monotherapy
| العنوان: | Development of asolectin-based liposomal formulation for controlled and targeted delivery of erlotinib as a model drug for EGFR monotherapy |
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| المؤلفون: | Snehal Pardeshi, Amrendra Tiwari, Uday Titame, Pankaj K Singh, Pavan Kumar Yadav, Manish K. Chourasia |
| المصدر: | Journal of Liposome Research. 32:386-395 |
| بيانات النشر: | Informa UK Limited, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | ErbB Receptors, Pancreatic Neoplasms, Erlotinib Hydrochloride, Cell Line, Tumor, Liposomes, Humans, Pharmaceutical Science, Protein Kinase Inhibitors |
| الوصف: | The present investigation was envisaged to develop liposomal formulation for efficacious and targeted delivery of epidermal growth factor receptor (EGFR) inhibitor (erlotinib) against pancreatic cancer. The marketed formulations bearing current EGFR inhibitors exhibit serious adverse effects including severe skin, hemolytic and gastrointestinal toxicity. To address the obstacles, we have developed the liposomal formulation, by ether injection method, comprising erlotinib, a tyrosine kinase EGFR inhibitor, proposed to be targeted through enhanced permeability and retention effect (EPR) effect against pancreatic cancer. On succeeding, the liposomes were characterized for various pharmaceutical attributes. The developed liposomes found to sustain a particle size of 121 ± 10.7 nm, whereas PDI of 0.22 ± 0.01 with the surface charge value of -33.7 ± 2.30 mV. The entrapment efficiency and drug loading were found to be 82.60 and 15.89 (%w/w), respectively. The hemolysis study suggested that the developed formulation was safer compared with native drug solution. The proof of concept for enhanced efficacy and decreased toxicity has been established through |
| تدمد: | 1532-2394 0898-2104 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca996ec4e0435cf96721a207410bf71e https://doi.org/10.1080/08982104.2022.2040532 |
| رقم الأكسشن: | edsair.doi.dedup.....ca996ec4e0435cf96721a207410bf71e |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15322394 08982104 |
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