Optical fibre‐enabled photoswitching for localised activation of an anti‐cancer therapeutic drug
| العنوان: | Optical fibre‐enabled photoswitching for localised activation of an anti‐cancer therapeutic drug |
|---|---|
| المؤلفون: | Andrew D. Abell, Loretta Scolaro, Carmela Ricciardelli, Noor A. Lokman, Weikun Huang, Alaknanda Adwal, Bryden C. Quirk, Martin K. Oehler, Robert A. McLaughlin, Kathryn A. Palasis |
| المساهمون: | Palasis, Kathryn A, Lokman, Noor A, Quirk, Bryden C, Adwal, Alaknanda, Scolaro, Loretta, Huang, Weikun, Ricciardelli, Carmela, Oehler, Martin K, McLaughlin, Robert A, Abell, Andrew D |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 10844, p 10844 (2021) International Journal of Molecular Sciences |
| بيانات النشر: | Switzerland : MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Drug, Optical fiber, Cell Survival, QH301-705.5, media_common.quotation_subject, optical fibres, Antineoplastic Agents, colorectal cancer, 01 natural sciences, Catalysis, law.invention, Inorganic Chemistry, 03 medical and health sciences, In vivo, law, Tumor Cells, Cultured, Fluorescence microscope, Humans, Dimethyl Sulfoxide, MTT assay, photopharmacology, Physical and Theoretical Chemistry, Biology (General), Cytotoxicity, Molecular Biology, QD1-999, Optical Fibers, Spectroscopy, 030304 developmental biology, media_common, 0303 health sciences, 010405 organic chemistry, Chemistry, Communication, Organic Chemistry, biophotonics, General Medicine, 3. Good health, 0104 chemical sciences, Computer Science Applications, photoswitches, Biophotonics, Cancer cell, Biophysics, Colorectal Neoplasms |
| الوصف: | Refereed/Peer-reviewed Local activation of an anti-cancer drug when and where needed can improve selectivity and reduce undesirable side effects. Photoswitchable drugs can be selectively switched between active and inactive states by illumination with light; however, the clinical development of these drugs has been restricted by the difficulty in delivering light deep into tissue where needed. Optical fibres have great potential for light delivery in vivo, but their use in facilitating photoswitching in anti-cancer compounds has not yet been explored. In this paper, a photoswitchable chemotherapeutic is switched using an optical fibre, and the cytotoxicity of each state is measured against HCT-116 colorectal cancer cells. The performance of optical-fibre-enabled photoswitching is characterised through its dose response. The UV–Vis spectra confirm light delivered by an optical fibre effectively enables photoswitching. The activated drug is shown to be twice as effective as the inactive drug incausing cancer cell death, characterised using an MTT assay and fluorescent microscopy. This is the first study in which a photoswitchable anti-cancer compound is switched using an optical fibre and demonstrates the feasibility of using optical fibres to activate photoswitchable drugs for potential future clinical applications. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9d719432aaaa0f08dd7560bf9d99a0 https://hdl.handle.net/11541.2/25973 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ca9d719432aaaa0f08dd7560bf9d99a0 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |