Liposome-encapsulated gentamicin treatment of Mycobacterium avium-Mycobacterium intracellulare complex bacteremia in AIDS patients
| العنوان: | Liposome-encapsulated gentamicin treatment of Mycobacterium avium-Mycobacterium intracellulare complex bacteremia in AIDS patients |
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| المؤلفون: | S X Cal, Stephen D. Nightingale, S L Saletan, D A Watson, E G Silverman, F G Pilkiewicz, C E Swenson, A J Lawrence |
| المصدر: | Antimicrobial Agents and Chemotherapy. 37:1869-1872 |
| بيانات النشر: | American Society for Microbiology, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Mycobacterium avium-intracellulare infection, Colony Count, Microbial, Bacteremia, Drug resistance, Gastroenterology, Internal medicine, Humans, Medicine, Pharmacology (medical), Infusions, Intravenous, Adverse effect, Mycobacterium avium-intracellulare Infection, Pharmacology, Acquired Immunodeficiency Syndrome, Drug Carriers, Chemotherapy, biology, business.industry, Aminoglycoside, Mycobacterium avium Complex, biology.organism_classification, medicine.disease, Surgery, Infectious Diseases, Liposomes, Female, Gentamicin, Gentamicins, business, Research Article, Mycobacterium, medicine.drug |
| الوصف: | TLC G-65, a liposome-encapsulated gentamicin, was given intravenously twice weekly for 4 weeks to AIDS patients with Mycobacterium avium-M. intracellulare complex (MAC) bacteremia at 1.7 mg of gentamicin per kg of body weight per infusion (4 patients), 3.4 mg/kg (10 patients), and 5.1 mg/kg (7 patients). MAC colony counts in blood fell by 75% or more in all three groups (P < 0.005). Drug resistance did not emerge during the study period. Transient renal insufficiency developed in one patient; no other adverse effects were detected. Liposome-encapsulated gentamicin is a potential therapy for MAC infections in AIDS patients. |
| تدمد: | 1098-6596 0066-4804 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab1e0b2887774b32db14f9f0c0e152c https://doi.org/10.1128/aac.37.9.1869 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cab1e0b2887774b32db14f9f0c0e152c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10986596 00664804 |
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