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Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction

التفاصيل البيبلوغرافية
العنوان: Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction
المؤلفون: Lidija Orlić, Vesna Lukenda, Martina Pavletić-Peršić, Sandra Milić, Sanjin Rački, Ivana Mikolašević
المصدر: Medical Hypotheses
Volume 82
Issue 1
بيانات النشر: Elsevier BV, 2014.
سنة النشر: 2014
مصطلحات موضوعية: medicine.medical_specialty, Population, Disease, Models, Biological, Gastroenterology, renal transplant recipients, Renin-Angiotensin System, Insulin resistance, Non-alcoholic Fatty Liver Disease, Chronic allograft nephropathy, Internal medicine, Non alcoholic fatty liver disease, medicine, Humans, education, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine, Metabolic Syndrome, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina, education.field_of_study, business.industry, Fatty liver, General Medicine, medicine.disease, Kidney Transplantation, Fatty Liver, Transplantation, Oxidative Stress, Endocrinology, Cardiovascular Diseases, Insulin Resistance, Primary Graft Dysfunction, Metabolic syndrome, business, Kidney disease
الوصف: Despite all improvements in transplant medicine, renal transplant recipients have a high risk for cardiovascular mortality. A high prevalence of cardiovascular complications in renal transplant recipients (RTR) is explained by cardiovascular risk factors present before transplantation, in addition to the development of new risk factors as well as worsening of preexisting risk factors after transplantation. A majority ot these patients develop metabolic syndrome within a year after the transplantation. The metabolic syndrome (MS) is associated with impaired renal allograft function and increased insulin resistance. Non alcoholic fatty liver disease (NAFLD) represents a liver manifestation of metabolic syndrome and it development is strongly associated with all components of MS in general population. The current importance of NAFLD and its link to the MS has encouraged an interest in its possible role in the development of atherosclerosis in recent years. Considering the fact that all components of MS are more common among renal transplant recipients compared to general population, it would be expected that RTR may have a much higher incidence of NAFLD compared to general population. We propose that the presence of NAFLD in RTR could be a strong predictor in cardiovascular morbidity and mortality. Also, according to the recent investigations about the possible link between NAFLD and chronic kidney disease, we hypothesis that NAFLD may be associated with deteriorating graft function, causing a chronic allograft nephropathy and graft loss. Common factors underlying the pathogenesis of NAFLD and chronic allograft dysfunction may be insulin resistance, oxidative stress, activation of rennin-angiotensin system, and inappropriate secretion of inflammatory cytokines by steatotic and inflamed liver. (C) 2013 Elsevier Ltd. All rights reserved.
وصف الملف: application/pdf
تدمد: 0306-9877
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac87c56538da05e1090453458fa22b6
https://doi.org/10.1016/j.mehy.2013.10.030
حقوق: RESTRICTED
رقم الأكسشن: edsair.doi.dedup.....cac87c56538da05e1090453458fa22b6
قاعدة البيانات: OpenAIRE
الوصف
تدمد:03069877