Fabrication and Biological Analysis of Highly Porous PEEK Bionanocomposites Incorporated with Carbon and Hydroxyapatite Nanoparticles for Biological Applications
| العنوان: | Fabrication and Biological Analysis of Highly Porous PEEK Bionanocomposites Incorporated with Carbon and Hydroxyapatite Nanoparticles for Biological Applications |
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| المؤلفون: | Ramazan Asmatulu, Paul H. Wooley, Nizam Uddin, Palanivel Swaminathan |
| المصدر: | Molecules Molecules, Vol 25, Iss 3572, p 3572 (2020) Volume 25 Issue 16 |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Scaffold, Materials science, Biocompatibility, Cell Survival, Polymers, 0206 medical engineering, Osteoclasts, Pharmaceutical Science, 02 engineering and technology, Carbon nanotube, Article, Nanocomposites, Polyethylene Glycols, Analytical Chemistry, law.invention, Nanomaterials, lcsh:QD241-441, Benzophenones, lcsh:Organic chemistry, PEEK, law, Drug Discovery, Cell Adhesion, Peek, Viability assay, Physical and Theoretical Chemistry, Bone regeneration, cell viability, Mechanical Phenomena, Nanocomposite, Nanotubes, Carbon, bionanocomposites, Organic Chemistry, hydroxyapatite, Ketones, 021001 nanoscience & nanotechnology, 020601 biomedical engineering, Durapatite, Chemical engineering, Chemistry (miscellaneous), Nanoparticles, cytotoxicity, Molecular Medicine, carbon particles, 0210 nano-technology, Porosity, bone marrow cell |
| الوصف: | Bone regeneration for replacing and repairing damaged and defective bones in the human body has attracted much attention over the last decade. In this research, highly porous polyetheretherketone (PEEK)/hydroxyapatite (HA) bionanocomposite scaffolds reinforced with carbon fiber (CF) and carbon nanotubes (CNTs) were fabricated, and their structural, mechanical, and biological properties were studied in detail. Salt porogen (200&ndash 500 µ m size) leaching methods were adapted to produce porous PEEK structures with controlled pore size and distribution, facilitating greater cellular infiltration and biological integration of PEEK composites within patient tissue. In biological tests, nanocomposites proved to be non-toxic and have very good cell viability. In addition, bone marrow cell growth was observed, and PEEK/HA biocomposites with carbon particles showed increased cell attachment over the neat PEEK/HA composites. In cell viability tests, bionanocomposites with 0.5 wt% CNTs established good attachment of cells on disks compared to neat PEEK/HA biocomposites. A similar performance was seen in culture tests of bone marrow cells (osteoblasts and osteoclasts). The 0.5 wt% CF for osteoblasts and 1 wt% CNTs for osteoclasts showed higher cell attachment. The addition of carbon-based nanomaterials into PEEK/HA has been identified as an effective approach to improve cell attachment as well as mechanical and biological properties. With confirmed cell attachment and sustained viability and proliferation of the fabricated PEEK/HA/CNTs, CF bionanocomposites were confirmed to possess excellent biocompatibility and will have potential uses in bone scaffolding and other biomedical applications. |
| وصف الملف: | application/pdf |
| تدمد: | 1420-3049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0fba930878240b1983fc90a9347f52 https://doi.org/10.3390/molecules25163572 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cb0fba930878240b1983fc90a9347f52 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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