Whole-body diffusion-weighted magnetic resonance imaging (WB-DW-MRI) vs choline-positron emission tomography-computed tomography (choline-PET/CT) for selecting treatments in recurrent prostate cancer
| العنوان: | Whole-body diffusion-weighted magnetic resonance imaging (WB-DW-MRI) vs choline-positron emission tomography-computed tomography (choline-PET/CT) for selecting treatments in recurrent prostate cancer |
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| المؤلفون: | R. Muelas-Soria, G Herrando-Parreño, F García-Piñón, J Ferrer-Rebolleda, M P Cozar-Santiago, Carlos Ferrer-Albiach, R Broseta-Torres, Antonio J. Conde-Moreno |
| المصدر: | CLINICAL & TRANSLATIONAL ONCOLOGY r-FHPC. Repositorio Institucional de Producción Científica de la Fundación del Hospital Provincial de Castellón instname |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Brachytherapy, WB-DW-MRI, Pilot Projects, SABR volatility model, Sensitivity and Specificity, 030218 nuclear medicine & medical imaging, Choline, Lesion, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Positron Emission Tomography Computed Tomography, medicine, Humans, External beam radiotherapy, Prospective Studies, Choline-PET/CT, Aged, Aged, 80 and over, medicine.diagnostic_test, business.industry, Prostatic Neoplasms, Magnetic resonance imaging, General Medicine, Middle Aged, medicine.disease, Diffusion Magnetic Resonance Imaging, Oncology, Bone scintigraphy, 030220 oncology & carcinogenesis, Radiology, Tomography, medicine.symptom, Neoplasm Recurrence, Local, Nuclear medicine, business, Oligometastases |
| الوصف: | To determine the effectiveness of whole-body diffusion-weighted magnetic resonance imaging (WB-DW-MRI) in detecting metastases by comparing the results with those from choline-positron emission tomography-computed tomography (choline-PET/CT) in patients with biochemical relapse after primary treatment, and no metastases in bone scintigraphy, CT and/or pelvic MRI, or metastatic/oligometastatic prostate cancer (PCa). Patients with this disease profile who could benefit from treatment with stereotactic body radiation therapy (SBRT) were selected and their responses to these techniques were rated. This was a prospective, controlled, unicentric study, involving 46 consecutive patients from our centre who presented biochemical relapse after adjuvant, salvage or radical treatment with external beam radiotherapy, or brachytherapy. After initial tests (bone scintigraphy, CT, pelvic MRI), 35 patients with oligometastases or without them were selected. 11 patients with multiple metastases were excluded from the study. WB-DW-MRI and choline-PET/CT was then performed on each patient within 1 week. The results were interpreted by specialists in nuclear medicine and MRI. If they were candidates for treatment with ablative SBRT (SABR), they were then evaluated every three months with both tests. Choline-PET/CT detected lesions in 16 patients that were not observable using WB-DW-MRI. The results were consistent in seven patients and in three cases, a lesion was observed using WB-DW-MRI that was not detected with choline-PET/CT. The Kappa value obtained was 0.133 (p = 0.089); the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of WB-DW-MRI were estimated at 44.93, 64.29, 86.11, and 19.15%, respectively. For choline-PET/CT patients, the sensitivity, specificity, PPV, and NPV were 97.10, 58.33, 93.06, and 77.78%, respectively. Choline-PET/CT has a high global sensitivity while WB-DW-MRI has a high specificity, and so they are complementary techniques. Future studies with more enrolled patients and a longer follow-up period will be required to confirm these data. The initial data show that the best technique for evaluating response after SBRT is choline-PET/CT. Trial registration number NCT02858128. |
| تدمد: | 1699-3055 1699-048X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb32f68b8353422e9b489069d289ede9 https://pubmed.ncbi.nlm.nih.gov/27796820 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cb32f68b8353422e9b489069d289ede9 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 16993055 1699048X |
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