Development of Poly(2-Methacryloyloxyethyl Phosphorylcholine)-Functionalized Hydrogels for Reducing Protein and Bacterial Adsorption
| العنوان: | Development of Poly(2-Methacryloyloxyethyl Phosphorylcholine)-Functionalized Hydrogels for Reducing Protein and Bacterial Adsorption |
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| المؤلفون: | Sung Cho, Jun-Pil Jee, Won Young Lee, Jung Suk Kim, Ho-Joong Kim, Gye Myung Lee, Temmy Pegarro Vales |
| المصدر: | Materials Volume 13 Issue 4 Materials, Vol 13, Iss 4, p 943 (2020) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | wettability, macromolecular substances, 02 engineering and technology, 010402 general chemistry, Methacrylate, complex mixtures, lcsh:Technology, 01 natural sciences, biomembrane-mimicking, Article, Adsorption, immune system diseases, General Materials Science, Bovine serum albumin, surface-functionalization, lcsh:Microscopy, lcsh:QC120-168.85, chemistry.chemical_classification, lcsh:QH201-278.5, biology, lcsh:T, Phosphorylcholine, technology, industry, and agriculture, Polymer, 021001 nanoscience & nanotechnology, protein adsorption, 0104 chemical sciences, chemistry, Chemical engineering, lcsh:TA1-2040, Self-healing hydrogels, biology.protein, Surface modification, lcsh:Descriptive and experimental mechanics, lcsh:Electrical engineering. Electronics. Nuclear engineering, hydrogel, lcsh:Engineering (General). Civil engineering (General), 0210 nano-technology, lcsh:TK1-9971, Protein adsorption |
| الوصف: | A series of hydrogels with intrinsic antifouling properties was prepared via surface-functionalization of poly(2-hydroxyethyl methacrylate) [p(HEMA)]-based hydrogels with the biomembrane-mimicking zwitterionic polymer, poly(2-methacryloyloxyethyl phosphorylcholine) [p(MPC)]. The p(MPC)-modified hydrogels have enhanced surface wettability, high water content retention (61.0%&ndash 68.3%), and good transmittance (> 90%). Notably, the presence of zwitterionic MPC moieties at the hydrogel surfaces lowered the adsorption of proteins such as lysozyme and bovine serum albumin (BSA) by 73%&ndash 74% and 59%&ndash 66%, respectively, and reduced bacterial adsorption by approximately 10%&ndash 73% relative to the unmodified control. The anti-biofouling properties of the p(MPC)-functionalized hydrogels are largely attributed to the dense hydration layer formed at the hydrogel surfaces by the zwitterionic moieties. Overall, the results demonstrate that biocompatible and antifouling hydrogels based on p(HEMA)-p(MPC) structures have promising potential for application in biomedical materials. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1996-1944 |
| DOI: | 10.3390/ma13040943 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4170160aa683ac323d782363e4bd1a |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cb4170160aa683ac323d782363e4bd1a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19961944 |
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| DOI: | 10.3390/ma13040943 |