Coordinated regulation of infection-related morphogenesis by the KMT2-Cre1-Hyd4 regulatory pathway to facilitate fungal infection
| العنوان: | Coordinated regulation of infection-related morphogenesis by the KMT2-Cre1-Hyd4 regulatory pathway to facilitate fungal infection |
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| المؤلفون: | Sibao Wang, Jingjing Chen, Lili Wang, Xuan Cao, Yiling Lai, Gang Wei |
| المصدر: | Science Advances |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Morphogenesis, Virulence, Biology, Microbiology, Fungal Proteins, Histones, 03 medical and health sciences, Gene Expression Regulation, Fungal, Epigenetics, Gene, Research Articles, 030304 developmental biology, Regulation of gene expression, 0303 health sciences, Appressorium, Multidisciplinary, 030306 microbiology, fungi, Fungi, SciAdv r-articles, Agriculture, Histone-Lysine N-Methyltransferase, Cell biology, Phenotype, Mycoses, Host-Pathogen Interactions, Regulatory Pathway, Transcription Factor Gene, Signal Transduction, Transcription Factors, Research Article |
| الوصف: | The KMT2-Cre1-Hyd4 regulatory pathway modulates infection-related morphogenesis and pathogenicity in an insecticidal fungus. Entomopathogenic fungi can overcome insecticide resistance and represent promising tools for the control of mosquitoes. Better understanding of fungus-mosquito interactions is critical for improvement of fungal efficacy. Upon insect cuticle induction, pathogenic fungi undergo marked infection-related morphological differentiation. However, regulatory mechanisms of fungal infection–related morphogenesis are poorly understood. Here, we show that a histone lysine methyltransferase KMT2 in Metarhizium robertsii (MrKMT2) is up-regulated upon cuticle induction. MrKMT2 plays crucial roles in regulating infection-related morphogenesis and pathogenicity by up-regulating the transcription factor gene Mrcre1 via H3K4 trimethylation during mosquito cuticle infection. MrCre1 further regulates the cuticle-induced gene Mrhyd4 to modulate infection structure (appressorium) formation and virulence. Overall, the MrKMT2-MrCre1-MrHyd4 regulatory pathway regulates infection-related morphogenesis and pathogenicity in M. robertsii. These findings reveal that the epigenetic regulatory mechanism plays a pivotal role in regulating fungal pathogenesis in insects, and provide new insights into molecular interactions between pathogenic fungi and insect hosts. |
| تدمد: | 2375-2548 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5f54fc74500804b78cede8a3ec936a https://doi.org/10.1126/sciadv.aaz1659 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cb5f54fc74500804b78cede8a3ec936a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23752548 |
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