Health-related motivational and behavioral processes associated with DNA methylation of the TNF gene
| العنوان: | Health-related motivational and behavioral processes associated with DNA methylation of the TNF gene |
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| المؤلفون: | Sarabjit S. Mastana, Bethan Hussey, Martin R. Lindley, Ian M. Taylor, Richard P Steel |
| المصدر: | Health Psychology. 39:68-76 |
| بيانات النشر: | American Psychological Association (APA), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Epigenomics, Male, medicine.medical_specialty, Health Behavior, Bisulfite sequencing, Biology, Young Adult, Exon, Internal medicine, medicine, Humans, Epigenetics, Gene, Applied Psychology, Aged, Motivation, Tumor Necrosis Factor-alpha, Methylation, DNA Methylation, Middle Aged, Psychiatry and Mental health, Endocrinology, CpG site, DNA methylation, Female, Tumor necrosis factor alpha |
| الوصف: | Objective: Epigenetics has been described as one of the most exciting areas of contemporary biology, and research has begun to explore whether epigenetic modifications are influenced by psychological processes. The present research explored the associations of health-related motivation and behavior with the DNA methylation of tumor necrosis factor (TNF) gene. Methods: Participants (N =88) completed questionnaires examining engagement with health-related behavior (i.e., physical activity, diet and smoking) and health-related motivation from the perspective of self-determination theory. They also provided a capillary blood sample for DNA extraction and analysis of four CpG sites via bisulfite conversion within exon 1 of TNF. Results: Health-related introjected regulation was not associated with TNF methylation (β =.13, p =.23). Health-related autonomous motivation was weakly but positively associated with TNF methylation (β =.18, p =.08). Indirect effects were identified in a subsequent step; autonomous motivation was positively associated with fruit consumption (β = .29, p = .004), negatively associated with smoking (β = -.22, p =.03) but not associated with physical activity (β = .10, p = .34). Moreover, TNF methylation was positively associated with lifetime physical activity (β = .18, p =.08) and negatively associated with smoking (β =-.23, p =.03). Direct effects of autonomous motivation on DNA methylation did not persist when these indirect effects were included (β =.09, p =.43). Conclusions: Results support the idea that autonomous motivation for health is associated with DNA methylation, albeit indirectly through tobacco consumption. |
| وصف الملف: | application/pdf |
| تدمد: | 1930-7810 0278-6133 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9ef8d6fe72f62c569f128834cbe5d5 https://doi.org/10.1037/hea0000795 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cb9ef8d6fe72f62c569f128834cbe5d5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19307810 02786133 |
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