Graphene, other carbon nanomaterials and the immune system: toward nanoimmunity-by-design
| العنوان: | Graphene, other carbon nanomaterials and the immune system: toward nanoimmunity-by-design |
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| المؤلفون: | Antonio Dominguez, Vincenzo Palermo, Gianaurelio Cuniberti, Bjoern Schumacher, Matthias Rieckher, Bengt Fadeel, Lucia Gemma Delogu, Alberto Bianco, Matteo Pasquali, Alejandro Criado, Hagen Eckert, Davide Bedognetti, Ester Vázquez, Marco Orecchioni, Tatiana Da Ros, Yiyong Mai, Giulia Franzoni, Akcan Istif, Arianna Gazzi, Cecilia Clementi, Silvia Ferrari, Paola Nicolussi, J. Stephen Yan, Maurizio Prato, Xinliang Feng, Donato Mancino, Guotao Peng, Matteo Andrea Lucherelli, Kostas Kostarelos, Laura Fusco, Isabella Anna Vacchi, Açelya Yilmazer, Ngoc Do Quyen Chau |
| المساهمون: | Immunopathologie et chimie thérapeutique (ICT), Centre National de la Recherche Scientifique (CNRS)-Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Gazzi, A., Fusco, L., Orecchioni, M., Ferrari, S., Franzoni, G., Yan, J. S., Rieckher, M., Peng, G., Lucherelli, M. A., Vacchi, I. A., Quyen Chau, N. D., Criado, A., Istif, A., Mancino, D., Dominguez, A., Eckert, H., Vazquez, E., Ros, T. D., Nicolussi, P., Palermo, V., Schumacher, B., Cuniberti, G., Mai, Y., Clementi, C., Pasquali, M., Feng, X., Kostarelos, K., Yilmazer, A., Bedognetti, D., Fadeel, B., Prato, M., Bianco, A., Delogu, L. G. |
| المصدر: | Journal of Physics: Materials Journal of Physics: Materials, IOP Science, 2020, 3 (3), pp.034009. ⟨10.1088/2515-7639/ab9317⟩ JPhys materials Online 3 (2020). doi:10.1088/2515-7639/ab9317 info:cnr-pdr/source/autori:Gazzi, Arianna; Fusco, Laura; Orecchioni, Marco; Ferrari, Silvia; Franzoni, Giulia; Yan, J. Stephen; Rieckher, Matthias; Peng, Guotao; Lucherelli, Matteo Andrea; Anna Vacchi, Isabella; Ngoc Do Quyen Chau; Criado, Alejandro; Istif, Akcan; Mancino, Donato; Dominguez, Antonio; Eckert, Hagen; Vazquez, Ester; Da Ros, Tatiana; Nicolussi, Paola; Palermo, Vincenzo; Schumacher, Bjoern; Cuniberti, Gianaurelio; Mai, Yiyong; Clementi, Cecilia; Pasquali, Matteo; Feng, Xinliang; Kostarelos, Kostas; Yilmazer, Acelya; Bedognetti, Davide; Fadeel, Bengt; Prato, Maurizio; Bianco, Alberto; Delogu, Lucia Gemma/titolo:Graphene, other carbon nanomaterials and the immune system: toward nanoimmunity-by-design/doi:10.1088%2F2515-7639%2Fab9317/rivista:JPhys materials Online/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:3 Gazzi, A, Fusco, L, Orecchioni, M, Ferrari, S, Franzoni, G, Yan, S, Rieckher, M, Peng, G, A.Lucherelli, M, Anna Vacchi, I, Quyen Chau, N D, Criado, A, Istif, A, Mancino, D, Dominguez, A, Eckert, H, Vazquez, E, da Ros, T, Nicolussi, P, Palermo, V, Schumacher, B, Cuniberti, G, Mai, Y, Clementi, C, Pasquali, M, Feng, X, Kostarelos, K, Yilmazer, A, Bedognetti, D, Fadeel, B, Prato, M, Bianco, A & Gemma Delogu, L 2020, ' Graphene, other carbon nanomaterials and the immune system : toward nanoimmunity-by-design ', Journal of Physics: Materials, vol. 3, no. 3, 034009, pp. 1-19 . https://doi.org/10.1088/2515-7639/ab9317 Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona |
| بيانات النشر: | IOP PUBLISHING LTD, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Engineering, Systems biology, Carbon fibers, Carbon nanotubes, 02 engineering and technology, Carbon nanotube, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Nanosafety, law.invention, 03 medical and health sciences, law, single cell mass cytometry, [CHIM]Chemical Sciences, General Materials Science, Nanotoxicology, graphene, carbon nanotubes, nanomedicine, nanosafety, nanotoxicology, systems biology, Carbon nanomaterials, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, Single cell mass cytometry, Graphene, business.industry, Nanomedicine, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, 3. Good health, Characterization (materials science), visual_art, visual_art.visual_art_medium, Biochemical engineering, 0210 nano-technology, business, Material chemistry |
| الوصف: | Carbon-based materials (CBMs), such as graphene, nanodiamonds, carbon fibers, and carbon dots, have attracted a great deal scientific attention due to their potential as biomedical tools. Following exposure, particularly intravenous injection, these nanomaterials can be recognized by immune cells. Such interactions could be modulated by the different physicochemical properties of the materials (e.g. structure, size, and chemical functions), by either stimulating or suppressing the immune response. However, a harmonized cutting-edge approach for the classification of these materials based not only on their physicochemical parameters but also their immune properties has been missing. The European Commission-funded G-IMMUNOMICS and CARBO-IMmap projects aimed to fill this gap, developing a functional pipeline for the qualitative and quantitative immune characterization of graphene, graphene-related materials (GRMs), and other CBMs. The goal was to open breakthrough perspectives for the definition of the immune profiles of these materials. Here, we summarize our methodological approach, key results, and the necessary multidisciplinary expertise ranging across various fields, from material chemistry to engineering, immunology, toxicology, and systems biology. G-IMMUNOMICS, as a partnering project of the Graphene Flagship, the largest scientific research initiative on graphene worldwide, also complemented the studies performed in the Flagship on health and environmental impact of GRMs. Finally, we present the nanoimmunity-by-design concept, developed within the projects, which can be readily applied to other 2D materials. Overall, the G-IMMUNOMICS and CARBO-IMmap projects have provided new insights on the immune impact of GRMs and CBMs, thus laying the foundation for their safe use and future translation in medicine. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2515-7639 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb05e4560ae6bf47270d11db74fbc86 http://hdl.handle.net/11577/3352630 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cbb05e4560ae6bf47270d11db74fbc86 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25157639 |
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