Acute and Sub-Chronic Toxicity of Aqueous Extracts ofChenopodium ambrosioidesLeaves in Rats
| العنوان: | Acute and Sub-Chronic Toxicity of Aqueous Extracts ofChenopodium ambrosioidesLeaves in Rats |
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| المؤلفون: | Carlos Campos Câmara, José Domingues Fontenele Neto, Raimundo Neilson de Lima Amorim, Marcel Gianni C da Silva, Benito Soto-Blanco |
| المصدر: | Journal of Medicinal Food. 17:979-984 |
| بيانات النشر: | Mary Ann Liebert Inc, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Medicine (miscellaneous), Aspartate transaminase, Pharmacology, chemistry.chemical_compound, Animals, Urea, Aspartate Aminotransferases, Rats, Wistar, Creatinine, Nutrition and Dietetics, Aqueous solution, biology, Plant Extracts, Chenopodium ambrosioides, Alanine Transaminase, Acute toxicity, Plant Leaves, Liver, Alanine transaminase, chemistry, Toxicity, biology.protein |
| الوصف: | The present study aimed to evaluate the toxicity of aqueous extract of Chenopodium ambrosioides leaves. To measure acute toxicity, rats were administered 0, 0.3, 1.0, or 3.0 g/kg of aqueous extract from C. ambrosioides leaves by gavage. To analyze sub-chronic toxicity, rats were treated by oral gavage for 15 consecutive days with 0, 0.3, or 1.0 g/kg of extract of C. ambrosioides leaves. No animals from either trial exhibited any signs of toxicity. In the acute study, the highest dose of the extract led to an increase in the serum activities of alanine transaminase (ALT) and aspartate transaminase (AST) and a decrease in the serum levels of urea. In the sub-chronic test, rats treated with 1.0 g/kg for 15 days exhibited increased serum ALT activity and creatinine levels and mild cytoplasmic vacuolation of hepatocytes. The results indicate that aqueous extract from C. ambrosioides leaves produce slight hepatotoxic lesions in rats. |
| تدمد: | 1557-7600 1096-620X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb2ad28ba3e13a1a98295fb21fc90cc https://doi.org/10.1089/jmf.2013.0134 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....cbb2ad28ba3e13a1a98295fb21fc90cc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15577600 1096620X |
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