Ivabradine augments high-frequency dynamic gain of the heart rate response to low- and moderate-intensity vagal nerve stimulation under β-blockade
| العنوان: | Ivabradine augments high-frequency dynamic gain of the heart rate response to low- and moderate-intensity vagal nerve stimulation under β-blockade |
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| المؤلفون: | Hiromi Yamamoto, Takuya Nishikawa, Toru Kawada, Meihua Li, Kazunori Uemura, Tadayoshi Miyamoto, Masaru Sugimachi, Can Zheng, Yohsuke Hayama |
| المصدر: | American Journal of Physiology-Heart and Circulatory Physiology. 320:H2201-H2210 |
| بيانات النشر: | American Physiological Society, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Potassium Channels, Physiology, Vagal nerve, Adrenergic beta-Antagonists, Stimulation, β blockade, Heart Rate, Physiology (medical), Internal medicine, Heart rate, Cyclic AMP, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels, medicine, Animals, Arterial Pressure, Ivabradine, Heart rate response, business.industry, Cardiovascular Agents, Vagus Nerve, Propranolol, Electric Stimulation, Rats, Intensity (physics), G Protein-Coupled Inwardly-Rectifying Potassium Channels, Cardiology, sense organs, Cardiology and Cardiovascular Medicine, business, medicine.drug |
| الوصف: | Our previous study indicated that intravenously administered ivabradine (IVA) augmented the dynamic heart rate (HR) response to moderate-intensity vagal nerve stimulation (VNS). Considering an accentuated antagonism, the results were somewhat paradoxical; i.e., the accentuated antagonism indicates that an activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels via the accumulation of intracellular cyclic adenosine monophosphate (cAMP) augments the HR response to VNS, whereas the inhibition of HCN channels by IVA also augmented the HR response to VNS. To remove the possible influence from the accentuated antagonism, we examined the effects of IVA on the dynamic vagal control of HR under β-blockade. In anesthetized rats ( |
| تدمد: | 1522-1539 0363-6135 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7e37d6c9cdbd0f651a56b9673c5db7 https://doi.org/10.1152/ajpheart.00057.2021 |
| رقم الأكسشن: | edsair.doi.dedup.....cc7e37d6c9cdbd0f651a56b9673c5db7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221539 03636135 |
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