Upregulation of des-gamma-carboxy-prothrombin after portal vein embolization in a cirrhotic patient with hepatocellular carcinoma
| العنوان: | Upregulation of des-gamma-carboxy-prothrombin after portal vein embolization in a cirrhotic patient with hepatocellular carcinoma |
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| المؤلفون: | Satoshi Shakado, Kengo Yoshimitsu, Shinichi Kora, Hideo Kunimoto, Jun Ohishi, Yasushi Yamauchi, Tetsuro Sohda, Kaoru Yotsumoto, Tomoaki Noritomi, Yasuaki Takeyama, Akira Anan, Keiji Yokoyama, Yuichi Yamashita, Kaoru Iwata, Shotaro Sakisaka, Akinobu Osame, Daisuke Morihara |
| المصدر: | Clinical Journal of Gastroenterology. 8:330-334 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Liver Cirrhosis, medicine.medical_specialty, Carcinoma, Hepatocellular, Percutaneous, medicine.medical_treatment, Gastroenterology, Downregulation and upregulation, Surgical oncology, Internal medicine, Hepatectomy, Humans, Medicine, Neoplasm Invasiveness, Protein Precursors, Aged, Portal Vein, business.industry, Liver Neoplasms, General Medicine, Hepatology, medicine.disease, Embolization, Therapeutic, Immunohistochemistry, digestive system diseases, Up-Regulation, Liver, Hepatocellular carcinoma, Female, Prothrombin, business, Biomarkers, Abdominal surgery |
| الوصف: | A 73-year-old female with hepatocellular carcinoma (HCC) received percutaneous transhepatic portal vein embolization (PTPE) before extensive right lobe hepatectomy. Serum levels of des-gamma-carboxy-prothrombin (DCP) were increased and remained at a high level until hepatectomy. Immunohistochemical examination revealed that an increased expression of DCP was demonstrated not only in HCC tissues, but also in the non-cancerous liver of the right lobe, where portal blood flow was blocked off as a result of PTPE. The serum level of DCP is known to be greatly increased in patients with HCC accompanied by portal vein invasion. We speculate that this increased DCP level is caused by both increased DCP production in HCC tissue and the surrounding non-cancerous liver, where portal flow is blocked off as a result of portal invasion by HCC. |
| تدمد: | 1865-7265 1865-7257 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc81b314bc25e3f3c80778cde8d46d04 https://doi.org/10.1007/s12328-015-0603-x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....cc81b314bc25e3f3c80778cde8d46d04 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 18657265 18657257 |
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