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Effects of CGS-12066A on medial vestibular nuclear neurons

التفاصيل البيبلوغرافية
العنوان: Effects of CGS-12066A on medial vestibular nuclear neurons
المؤلفون: Han-Seong Jeong, Jong-Seong Park, Myung-Joo Jang
المصدر: Brain Research. 1038:118-121
بيانات النشر: Elsevier BV, 2005.
سنة النشر: 2005
مصطلحات موضوعية: Agonist, Patch-Clamp Techniques, Potassium Channels, medicine.drug_class, Potassium, Medial vestibular nucleus, Action Potentials, chemistry.chemical_element, Rats, Sprague-Dawley, CGS-12066A, chemistry.chemical_compound, Organ Culture Techniques, Vestibular nuclei, Quinoxalines, medicine, Animals, Molecular Biology, Neurons, Membrane potential, Chemistry, General Neuroscience, Vestibular pathway, Vestibular Nuclei, Rats, Serotonin Receptor Agonists, medicine.anatomical_structure, Biophysics, Calcium, Neurology (clinical), Neuron, Neuroscience, Developmental Biology
الوصف: This study aims to explore the effects of a selective 5-HT1B receptor agonist, CGS-12066A, on the neuronal excitability of the rat medial vestibular nuclear neurons. The spontaneous firing rate was decreased, and the membrane potential was hyperpolarized by CGS-12066A. The whole potassium currents were inhibited by CGS-12066A. After the calcium-dependent potassium, currents were blocked, however, CGS-12066A did not inhibit the potassium currents, suggesting that the 5-HT action site is calcium-dependent potassium currents.
تدمد: 0006-8993
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc97bf8d47c9d96bed8f27a364cc71b4
https://doi.org/10.1016/j.brainres.2005.01.025
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....cc97bf8d47c9d96bed8f27a364cc71b4
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00068993