Evaluation of Lateral-Flow Assay for Rapid Detection of Influenza Virus
| العنوان: | Evaluation of Lateral-Flow Assay for Rapid Detection of Influenza Virus |
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| المؤلفون: | Jia-Xin Li, Meng-Yi Han, Tian-Ao Xie, Xu-Guang Guo, Hui-Jin Chen, Xiao-Hui Yang |
| المصدر: | BioMed Research International, Vol 2020 (2020) BioMed Research International |
| بيانات النشر: | Hindawi Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Article Subject, 030106 microbiology, Cochrane Library, Likelihood ratios in diagnostic testing, Sensitivity and Specificity, General Biochemistry, Genetics and Molecular Biology, Virus, 03 medical and health sciences, Orthomyxoviridae Infections, Medicine, Animals, Humans, General Immunology and Microbiology, Receiver operating characteristic, business.industry, Area under the curve, General Medicine, Publication bias, Orthomyxoviridae, Virology, 030104 developmental biology, ROC Curve, Area Under Curve, Diagnostic odds ratio, Respiratory virus, business, Research Article |
| الوصف: | Background. Influenza virus mainly causes acute respiratory infections in humans. However, the diagnosis of influenza is not accurate based on clinical evidence, as the symptoms of flu are similar to other respiratory virus. The lateral-flow assay is a rapid method to detect influenza virus. But the effectiveness of the technique in detecting flu viruses is unclear. Hence, a meta-analysis would be performed to evaluate the accuracy of LFA in detecting influenza virus. Methods. Relevant literature was searched out in PubMed, Embase, Web of Science, and Cochrane Library databases with the keywords “lateral flow assay” and “flu virus”. By Meta-DiSc software, pooled sensitivity, pooled specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), summary receiver operating characteristic curve (SROC), and area under the curve (AUC) can be calculated. Results. This meta-analysis contains 13 studies and 24 data. The pooled sensitivity and specificity of the influenza virus detected by LFA were 0.84 (95% CI: 0.82-0.86) and 0.97 (95% CI: 0.97-0.98), respectively. The pooled values of PLR, NLR, DOR, and SROC were 32.68 (17.16-62.24), 0.17 (0.13-0.24), 334.07 (144.27-773.53), and 0.9877. No publication bias was found. Conclusions. LFA exhibited high sensitivity and specificity in diagnosing influenza virus. It is a valuable alternative method which can diagnose influenza virus quickly. However, more evidence is required to confirm whether LFA is comparable to traditional methods for detecting the virus. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 2314-6141 2314-6133 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb139cb0e204d2e5567561e4312b895 https://doaj.org/article/9043a12d16194c4b826a261071ba520b |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ccb139cb0e204d2e5567561e4312b895 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146141 23146133 |
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