Effects of Immunoglobulin Preparations on the Opsonic Activities against Various Pathogens
| العنوان: | Effects of Immunoglobulin Preparations on the Opsonic Activities against Various Pathogens |
|---|---|
| المؤلفون: | Yasuo Ono, Isao Ouyatsu, Masumi Baba, Otohiko Kunii, Toshiaki Haga, Atsuko Guuji, Hajime Nishiya, Norio Nozue, Kunio Kobayashi, Yuichirou Ueda |
| المصدر: | Journal of the Japanese Association for Infectious Diseases. 64:854-860 |
| بيانات النشر: | The Japanese Association for Infectious Diseases, 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | Bacteria, biology, Neutrophils, Chemistry, Phagocytosis, Immunoglobulins, General Medicine, Opsonin Proteins, biology.organism_classification, In vitro, Antibody opsonization, In vivo, hemic and lymphatic diseases, Immunology, biology.protein, Humans, Antibody, Candida albicans, Opsonin, Whole blood |
| الوصف: | We evaluated the opsonic activities of human intravenous immunoglobulin (IVIG) preparations against pathogenic organisms by measuring the luminol-enhanced chemiluminescence (CL) from human polymorphonuclear leukocytes (PMN) during the phagocytosis of these organisms. Polyethylenglycol-treated IVIG significantly increased the CL of PMN by opsonization against various bacteria and Candida albicans (p less than 0.01). The high CL induced by IVIG with intact Fc-fragment showed no significant differences among lots or preparations made by different treatments. In both PMN-CL in the absence of human serum and whole blood CL at low concentration of serum complement, the CL response was not affected by pepsin-treated IVIG. In the severely burned patients' blood with a very low concentration of serum immunoglobulin, IVIG with intact Fc-fragment significantly increased CL (p less than 0.01). It is suggested that administration of IVIG is useful against infections in these patients. The measurement of whole blood CL in vitro may be useful for evaluating the opsonic activity of IVIG against target pathogens in vivo. |
| تدمد: | 1884-569X 0387-5911 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb39da548865cc3eb67f5966ff1f572 https://doi.org/10.11150/kansenshogakuzasshi1970.64.854 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ccb39da548865cc3eb67f5966ff1f572 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1884569X 03875911 |
|---|