التفاصيل البيبلوغرافية
العنوان:
Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues
المؤلفون:
Zhixiong Ye , Elizabeth T. Birzin , Meng-Hsin Chen , Louis Locco , Sheng-Shung Pong , Ravi P. Nargund , Rupa M. Parmar , Roy G. Smith , Ying-Duo Gao , Scott D. Feighner , Wanda W.-S. Chan , James M. Schaeffer , Arthur A. Patchett , Raman K. Bakshi , Allan D. Blake , Andrew D. Howard , Susan P. Rohrer
المصدر:
Bioorganic & Medicinal Chemistry Letters . 10:5-8
بيانات النشر:
Elsevier BV, 2000.
سنة النشر:
2000
مصطلحات موضوعية:
Models, Molecular , Agonist , Molecular model , medicine.drug_class , Clinical Biochemistry , Pharmaceutical Science , Receptors, Cell Surface , Carboxamide , Pharmacology , Biochemistry , Chemical synthesis , Receptors, G-Protein-Coupled , Inhibitory Concentration 50 , Structure-Activity Relationship , chemistry.chemical_compound , Drug Discovery , medicine , Animals , Humans , Potency , Receptors, Ghrelin , Molecular Biology , Quinazolinone , Binding Sites , Human Growth Hormone , Chemistry , Organic Chemistry , In vitro , Rats , Kinetics , Drug Design , Quinazolines , Molecular Medicine , Secretagogue , Secretory Rate
الوصف:
Quinazolinone derivatives were synthesized and evaluated as non-peptidic growth hormone secretagogues. Modeling guided design of quinazolinone compound 21 led to a potency enhancement of greater than 200-fold compared to human growth hormone secretagogue affinity of a screening lead 4.
تدمد:
0960-894X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb965f4e0f30dfe4382a988470dcd5a https://doi.org/10.1016/s0960-894x (99)00584-3
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....ccb965f4e0f30dfe4382a988470dcd5a
قاعدة البيانات:
OpenAIRE
