Tritherapy with fluorouracil/leucovorin, irinotecan and oxaliplatin (FOLFIRINOX): a phase II study in colorectal cancer patients with non-resectable liver metastases
| العنوان: | Tritherapy with fluorouracil/leucovorin, irinotecan and oxaliplatin (FOLFIRINOX): a phase II study in colorectal cancer patients with non-resectable liver metastases |
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| المؤلفون: | Rosine Guimbaud, Andrew Kramar, G. Portier, F. Viret, F. Quénet, Françoise Desseigne, Jean-Robert Delpero, Michel Rivoire, M. Ychou, Emmanuel Mitry, Bernard Nordlinger |
| المصدر: | Cancer Chemotherapy and Pharmacology. 62:195-201 |
| بيانات النشر: | Springer Science and Business Media LLC, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, medicine.medical_specialty, Organoplatinum Compounds, Colorectal cancer, FOLFIRINOX, medicine.medical_treatment, Leucovorin, Irinotecan, Toxicology, Gastroenterology, Disease-Free Survival, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Pharmacology (medical), Aged, Pharmacology, business.industry, Liver Neoplasms, Middle Aged, medicine.disease, Oxaliplatin, Surgery, Regimen, Oncology, Fluorouracil, Camptothecin, Female, Hepatectomy, Colorectal Neoplasms, business, Febrile neutropenia, medicine.drug |
| الوصف: | To assess the rate of R(0) resection of liver metastases achieved after chemotherapy with FOLFIRINOX.Patients with histologically proven primary colorectal cancer and bidimensionally measurable liver metastasis, not fully resectable based on technical inability to achieve R(0) resection, but potentially resectable after tumor reduction, were given FOLFIRINOX: oxaliplatin 85 mg/m(2), irinotecan 180 mg/m(2), leucovorin 400 mg/m(2), bolus fluorouracil 400 mg/m(2) and fluorouracil 46-h continuous IV infusion 2,400 mg/m(2), every 2 weeks for a maximum of 12 cycles.Thirty-four patients were enrolled. Response rate before surgery was 70.6% (95%CI: 52.5-84.9). Twenty-eight patients (82.4%) underwent hepatic resection and nine achieved R(0) resection [26.5% (95% CI: 12.9-44.4%)]. The rate of clinical complete remission after surgery was 79.4%. Two-year overall survival was 83%. The most frequent grade 3 or 4 toxicities were neutropenia (64.8%), diarrhea (29.4%), fatigue (23.5%), abdominal cramps (14.7%), neuropathy and nausea (11.8% each), and AST/ALT elevation (14.7/11.8%). Only one patient experienced febrile neutropenia, four patients withdrew due to toxicity and no toxic death was observed.FOLFIRINOX, with an acceptable toxicity profile, shows a high response rate in liver metastases from colorectal cancer. The rate of hepatic resection in patients initially not resectable, is attractive and warrants further assessment of this regimen in randomized studies compared to standard regimens. |
| تدمد: | 1432-0843 0344-5704 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce3367b48dcafecd22e35fe0b3f49fc https://doi.org/10.1007/s00280-007-0588-3 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....cce3367b48dcafecd22e35fe0b3f49fc |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14320843 03445704 |
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