أعرض في EDS

Significantly increased antibody response to heterogeneous nuclear ribonucleoproteins in cerebrospinal fluid of multiple sclerosis patients but not in patients with human T-lymphotropic virus type I–associated myelopathy/tropical spastic paraparesis

التفاصيل البيبلوغرافية
العنوان: Significantly increased antibody response to heterogeneous nuclear ribonucleoproteins in cerebrospinal fluid of multiple sclerosis patients but not in patients with human T-lymphotropic virus type I–associated myelopathy/tropical spastic paraparesis
المؤلفون: Shuji Izumo, Mineki Saito, Naoko Sueoka-Aragane, Eisaburo Sueoka, Yusuke Yakushiji, Motohiro Yukitake, Hiromi Ohashi, Akemi Sato, Yasuo Kuroda, Mitsuhiro Osame
المصدر: Journal of Neurovirology. 14:130-135
بيانات النشر: Springer Science and Business Media LLC, 2008.
سنة النشر: 2008
مصطلحات موضوعية: Pathology, medicine.medical_specialty, Multiple Sclerosis, viruses, Human T-lymphotropic virus, Heterogeneous-Nuclear Ribonucleoproteins, Virus, Central nervous system disease, Random Allocation, Cellular and Molecular Neuroscience, Myelopathy, Cerebrospinal fluid, immune system diseases, Virology, Tropical spastic paraparesis, medicine, Humans, Autoantibodies, Human T-lymphotropic virus 1, biology, business.industry, Multiple sclerosis, Brain, virus diseases, medicine.disease, biology.organism_classification, Paraparesis, Tropical Spastic, HTLV-I Antibodies, Neurology, Antibody Formation, Immunology, biology.protein, Neurology (clinical), Antibody, business
الوصف: It has been reported that antibodies (Abs) against heterogeneous nuclear ribonucleoproteins (hnRNPs) are associated with human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and multiple sclerosis (MS). However, these studies were done under nonmasked conditions. In order to determine whether Abs against hnRNPs associate with HAM/TSP and MS, the authors assayed Abs against two major hnRNPs, hnRNP A1 and A2/B1, in 105 cerebrospinal fluid (CSF) samples under fully masked conditions. Samples included 40 cases of HAM/TSP, 28 of MS, and 37 of other neurological diseases. Anti-hnRNP A1 Abs, and especially anti-hnRNP A2/B1 Abs, were found significantly more often in the CSF of MS patients than in other groups. However, there was no difference in the incidence of anti-hnRNP A1 Abs between HAM/TSP and other disease groups.
تدمد: 1538-2443
1355-0284
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf005f016ed912a04e8f92b3ba0fcea
https://doi.org/10.1080/13550280701883840
رقم الأكسشن: edsair.doi.dedup.....ccf005f016ed912a04e8f92b3ba0fcea
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15382443
13550284