Collagenase clostridium histolyticum for the treatment of Peyronie's disease: a prospective Italian multicentric study
| العنوان: | Collagenase clostridium histolyticum for the treatment of Peyronie's disease: a prospective Italian multicentric study |
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| المؤلفون: | Giulio Garaffa, Alessandro Palmieri, Gianluca Giubilei, Giovanna Russo, Francesco Sessa, Riccardo Campi, Nicola Mondaini, F. Di Maida, Paolo Verze, Massimiliano Timpano, Giovanni Tasso, Gianmartin Cito, Marco Falcone, Marco Capece, Giovanni Cacciamani, Vincenzo Mirone, T. Tony Cai, Bruno Giammusso, David Ralph, Girolamo Morelli, Andrea Cocci |
| المساهمون: | Capece, M., Cocci, A., Russo, G., Cito, G., Giubilei, G., Cacciamani, G., Garaffa, G., Falcone, M., Timpano, M., Tasso, G., Sessa, F., Campi, R., Di Maida, F., Cai, T., Morelli, G., Giammusso, B., Verze, P., Palmieri, A., Ralph, D., Mirone, V., Mondaini, N. |
| المصدر: | Andrology. 6:564-567 |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, collagenase clostridium histolyticum, erectile dysfunction, Peyronie's disease, Urology, Endocrinology, Diabetes and Metabolism, Penile Induration, 030232 urology & nephrology, sexual function, Xiapex, Young Adult, 03 medical and health sciences, penis, 0302 clinical medicine, Endocrinology, Collagenase clostridium histolyticum, Deformity, Humans, Medicine, Young adult, penile curvature, Aged, 030219 obstetrics & reproductive medicine, business.industry, Xiaflex, Middle Aged, medicine.disease, Peni, Surgery, collagenase, Microbial Collagenase, Treatment Outcome, Erectile dysfunction, medicine.anatomical_structure, Italy, Reproductive Medicine, Penile curvature, medicine.symptom, business, Sexual function, Penis, Human, medicine.drug |
| الوصف: | Peyronie's disease (PD) is a common condition which results in penile curvature making sexual intercourse difficult or impossible. Collagenase clostridium histolyticum (CCH) is the first licensed drug for the treatment of PD and is indicated in patients with palpable plaque and curvature deformity of at least 30° of curvature. However, only few monocentric studies are available in the current literature and this is the first national multicentric study focusing on this new treatment. In five Italian centres, 135 patients have completed the treatment with three injections of CCH using Ralph's shortened modified protocol. The protocol consisted of three intralesional injections of CCH (0.9 mg) given at 4-weekly intervals in addiction to a combination of home modelling, stretching and a vacuum device on a daily basis. An improvement in the angle of curvature was recorded in 128/135 patients (94.8%) by a mean (range) of 19.1 (0–40)° or 42.9 (0–67)% from baseline (p |
| تدمد: | 2047-2919 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0050b8232dc9fa138c5d3cbf580ec8 https://doi.org/10.1111/andr.12497 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cd0050b8232dc9fa138c5d3cbf580ec8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20472919 |
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