Putative Malignant Pleural Mesothelioma in situ (MPMIS) with Sequential Acquisition of Genomic Alterations on Fluorescence in situ Hybridization (FISH) Examination
| العنوان: | Putative Malignant Pleural Mesothelioma in situ (MPMIS) with Sequential Acquisition of Genomic Alterations on Fluorescence in situ Hybridization (FISH) Examination |
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| المؤلفون: | Spasenija Savice Prince, Heinz Borer, Simon Haefliger, Julien Rebetez, Lukas Bubendorf |
| المصدر: | Acta Cytol |
| بيانات النشر: | S. Karger AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | In situ, Pathology, medicine.medical_specialty, BAP1, Histology, medicine.diagnostic_test, business.industry, Context (language use), General Medicine, 030224 pathology, Pathology and Forensic Medicine, Lesion, 03 medical and health sciences, 0302 clinical medicine, Novel Insights from Clinical Practice, CDKN2A, Tumor progression, 030220 oncology & carcinogenesis, medicine, medicine.symptom, business, Mesothelial Cell, Fluorescence in situ hybridization |
| الوصف: | Malignant pleural mesothelioma (MPM) is a rare and deadly disease. A precursor in situ lesion, malignant pleural mesothelioma in situ (MPMIS), has recently been proposed. On cytological examination, the distinction between reactive and malignant mesothelial cells is often challenging, and sometimes even impossible without ancillary methods. Fluorescence in situ hybridization (FISH) for detection of 9p21 deletion is a powerful diagnostic tool in this context, both in histological and in cytological specimens. Here, we present a case of MPM with initial presentation as a putative MPMIS with disomic chromosomal pattern and homozygous 9p21 deletion with subsequent development of an aneuploid pattern after whole genome duplication during tumor progression. |
| تدمد: | 1938-2650 0001-5547 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd41751af90c0fdbf4f35c9c9c31e035 https://doi.org/10.1159/000509886 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cd41751af90c0fdbf4f35c9c9c31e035 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19382650 00015547 |
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