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Long-term treatment of chronic orofacial, pudendal, and central neuropathic limb pain with repetitive transcranial magnetic stimulation of the motor cortex

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العنوان: Long-term treatment of chronic orofacial, pudendal, and central neuropathic limb pain with repetitive transcranial magnetic stimulation of the motor cortex
المؤلفون: Jean-François Payen, Enkelejda Hodaj, Anne Dumolard, Caroline Maindet, Chantal Delon-Martin, Hasan Hodaj, Jean-Pascal Lefaucheur, Jean-Luc Cracowski
المساهمون: CHU Grenoble, [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre d'Investigation Clinique [Grenoble] (CIC Grenoble), CHU Grenoble-Hôpital Michallon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Excitabilité nerveuse et thérapeutique (ENT), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-EA 4391, Service de Physiologie Explorations Fonctionnelles-Hôpital Henri Mondor, Hôpital Henri Mondor-EA 4391, Service de Physiologie Explorations Fonctionnelles-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)
المصدر: Clinical Neurophysiology
Clinical Neurophysiology, Elsevier, 2020, 131, pp.1423-1432. ⟨10.1016/j.clinph.2020.03.022⟩
بيانات النشر: HAL CCSD, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Male, Orofacial pain, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Analgesic, 050105 experimental psychology, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Facial Pain, Physiology (medical), medicine, Humans, 0501 psychology and cognitive sciences, Aged, Pudendal Neuralgia, business.industry, Mononeuropathies, 05 social sciences, Pudendal neuralgia, Motor Cortex, Chronic pain, Extremities, Middle Aged, medicine.disease, Transcranial Magnetic Stimulation, Sensory Systems, Transcranial magnetic stimulation, medicine.anatomical_structure, Neurology, Anesthesia, Neuropathic pain, Quality of Life, Female, Neurology (clinical), Chronic Pain, medicine.symptom, business, 030217 neurology & neurosurgery, Motor cortex
الوصف: Objective To assess the long-term analgesic effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) of the motor cortex in patients with chronic pain syndrome. Methods The study included 57 patients (orofacial pain, n = 26, pudendal neuralgia, n = 18, and neuropathic limb pain, n = 13) with an “induction phase” of 12 daily rTMS sessions for 3 weeks, followed by a “maintenance phase” of bi-monthly sessions for the next five months. Results All pain measures significantly decreased from baseline to the end of the induction phase. Analgesic response, defined as pain intensity decrease ≥ 30% compared to baseline, was observed in 39 patients (68%), who could be differentiated from non-responders from the 7th rTMS session. At the end of the maintenance phase (D180), 27 patients (47%) were still responders. Anxio-depressive symptoms and quality of life also improved. The analgesic response at the end of the induction phase was associated with lower pain score at baseline, and the response at the end of the maintenance phase was associated with lower anxio-depressive score at baseline. Conclusion The analgesic efficacy of motor cortex rTMS can be maintained in the long term in various chronic pain conditions. Patients with high pain level and severe anxio-depressive symptoms may have a less favorable profile to respond to the procedure. Significance The overall impact of rTMS treatment on daily life requires a multidimensional evaluation that goes beyond the analgesic effect that can be achieved.
اللغة: English
تدمد: 1388-2457
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4966129cf8a0aeb2135584c4440f32
https://hal.archives-ouvertes.fr/hal-03490923
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....cd4966129cf8a0aeb2135584c4440f32
قاعدة البيانات: OpenAIRE
الوصف
تدمد:13882457