Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus
| العنوان: | Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus |
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| المؤلفون: | Yasuhiro Minami, Mitsuru Morimoto, Masaru Tamura, Mayo Shigeta, Keishi Kishimoto, Michiru Nishita, Akira Yamaoka, Takaya Abe |
| المصدر: | Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018) Nature Communications |
| بيانات النشر: | Nature Publishing Group, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Cellular differentiation, Golgi Apparatus, General Physics and Astronomy, Mice, Cell polarity, Morphogenesis, Myocyte, lcsh:Science, Multidisciplinary, Chemistry, Cell Polarity, Gene Expression Regulation, Developmental, Cell Differentiation, Forkhead Transcription Factors, SOX9 Transcription Factor, respiratory system, Cell biology, Trachea, Actin Cytoskeleton, medicine.anatomical_structure, Tube morphogenesis, Female, Signal Transduction, Science, Myocytes, Smooth Muscle, Mice, Transgenic, Nerve Tissue Proteins, Cartilage metabolism, Receptor Tyrosine Kinase-like Orphan Receptors, Article, Wnt-5a Protein, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Esophagus, medicine, Animals, Radial polarization, Progenitor cell, Cartilage, Mesenchymal stem cell, Mesenchymal Stem Cells, Muscle, Smooth, General Chemistry, Embryo, Mammalian, 030104 developmental biology, lcsh:Q, Developmental biology |
| الوصف: | Tube morphogenesis is essential for internal-organ development, yet the mechanisms regulating tube shape remain unknown. Here, we show that different mechanisms regulate the length and diameter of the murine trachea. First, we found that trachea development progresses via sequential elongation and expansion processes. This starts with a synchronized radial polarization of smooth muscle (SM) progenitor cells with inward Golgi-apparatus displacement regulates tube elongation, controlled by mesenchymal Wnt5a-Ror2 signaling. This radial polarization directs SM progenitor cell migration toward the epithelium, and the resulting subepithelial morphogenesis supports tube elongation to the anteroposterior axis. This radial polarization also regulates esophageal elongation. Subsequently, cartilage development helps expand the tube diameter, which drives epithelial-cell reshaping to determine the optimal lumen shape for efficient respiration. These findings suggest a strategy in which straight-organ tubulogenesis is driven by subepithelial cell polarization and ring cartilage development. Tracheal development arises due to tube morphogenesis but how this is regulated is unclear. Here, the authors identify polarization of smooth muscle progenitors as controlling murine tracheal development, activating noncanonical Wnt signaling followed by subepithelial morphogenesis and ring cartilage development. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2041-1723 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd774e928641d09f1864845d18378e65 http://link.springer.com/article/10.1038/s41467-018-05189-2 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cd774e928641d09f1864845d18378e65 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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