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Genetic variants associated with adult blood pressure and kidney function do not affect fetal kidney volume. The Generation R Study

التفاصيل البيبلوغرافية
العنوان: Genetic variants associated with adult blood pressure and kidney function do not affect fetal kidney volume. The Generation R Study
المؤلفون: Albert J. van der Heijden, Vincent W. V. Jaddoe, Albert Hofman, Leontine C. L. van den Hil, H. Rob Taal
المساهمون: Epidemiology, Erasmus MC other, Pediatrics
المصدر: Early Human Development, 88(9), 711-716. Elsevier Ireland Ltd
سنة النشر: 2012
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Kidney development, Pregnancy Trimester, Third, Renal function, Kidney Volume, Kidney, Ultrasonography, Prenatal, Fetal Kidney, Young Adult, Kidney function, Pregnancy, Internal medicine, Ultrasound, Obstetrics and Gynaecology, Kidney volume, medicine, Humans, Pediatrics, Perinatology, and Child Health, Fetus, business.industry, urogenital system, Infant, Newborn, Genetic Variation, Obstetrics and Gynecology, Nephron number, medicine.disease, Endocrinology, Blood pressure, Common genetic variants, Pregnancy Trimester, Second, Hypertension, Pediatrics, Perinatology and Child Health, Female, Kidney Diseases, Generation R, business, Kidney disease
الوصف: Background: Smaller kidneys with reduced number of nephrons in early life lead to impaired kidney function and risk for hypertension and chronic kidney disease. These associations might be partly explained by common genetic variation. Aims: To assess the associations between common genetic variants, which have recently shown to be associated with blood pressure or kidney function, with fetal kidney volume. Study design: A prospective population based cohort study in Rotterdam, The Netherlands. Subjects: 855 children, followed from early fetal life onwards (born 2003-2005). Predictor: Common genetic variants previously associated with blood pressure or kidney function. Outcome measures: Combined third trimester fetal kidney volume. Results: After taking into account multiple testing, only rs12940887 (near ZNF652) was significantly associated with fetal kidney volume (beta: 0.88 (95% CI: 0.40; 1.37) cm(3) per minor allele, P-value
وصف الملف: application/pdf
تدمد: 2003-2005
0378-3782
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda92d9ad3411147c53a7958ca0a9681
https://pure.eur.nl/en/publications/a116d497-d734-4c34-96c6-7f557924d14b
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....cda92d9ad3411147c53a7958ca0a9681
قاعدة البيانات: OpenAIRE
الوصف
تدمد:20032005
03783782