In vitro analysis of Epstein-Barr virus: Host balance in patients with acutePlasmodium falciparum malaria
| العنوان: | In vitro analysis of Epstein-Barr virus: Host balance in patients with acutePlasmodium falciparum malaria |
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| المؤلفون: | W. R. C. Weir, C. A. Facer, D. E. Gunapala, R. Davidson |
| المصدر: | Parasitology Research. 76:531-535 |
| بيانات النشر: | Springer Science and Business Media LLC, 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | Adult, Herpesvirus 4, Human, Adolescent, Plasmodium falciparum, Population, Lymphocyte Activation, medicine.disease_cause, Virus, Herpesviridae, Leukocyte Count, parasitic diseases, Immune Tolerance, medicine, Animals, Humans, Lymphocytes, Child, education, education.field_of_study, General Veterinary, biology, Herpesviridae Infections, General Medicine, Middle Aged, biology.organism_classification, medicine.disease, Burkitt Lymphoma, Virology, Epstein–Barr virus, Malaria, Lymphoma, Infectious Diseases, Insect Science, Acute Disease, Immunology, Regression Analysis, Parasitology, CD8, T-Lymphocytes, Cytotoxic |
| الوصف: | Peripheral blood lymphocytes from healthy, Epstein-Barr virus (EB-virus)-seropositive donors and from patients with acute Plasmodium falciparum malaria were tested for their cytotoxicity towards autologous EB-virus-infected B-cells using an in vitro regression assay. Of the 18 cultures from control donors, 88.8% showed the normal pattern of regression. Of the 20 malaria patients in the study, 40% failed to exhibit the normal pattern observed in the control group. Analysis of the lymphocyte subsets showed a high incidence of inverted CD4:CD8 ratios in the patient group due to an absolute rise in the CD8 population. This data suggests that the immunosuppressive effects of acute malaria extend to defective control over EB-virus. The relevance of the observations to the aetiology of EB-virus-associated, endemic Burkitt's lymphoma (eBL) is discussed. |
| تدمد: | 1432-1955 0044-3255 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb49c404d197893d229180fd8f4d020 https://doi.org/10.1007/bf00931060 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....cdb49c404d197893d229180fd8f4d020 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14321955 00443255 |
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