Implications of Standardized Uptake Values of Oral Squamous Cell Carcinoma in PET-CT on Prognosis, Tumor Characteristics and Mitochondrial DNA Heteroplasmy
| العنوان: | Implications of Standardized Uptake Values of Oral Squamous Cell Carcinoma in PET-CT on Prognosis, Tumor Characteristics and Mitochondrial DNA Heteroplasmy |
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| المؤلفون: | Hansi Weissensteiner, Liane Fendt, Emanuel Bruckmoser, Roy-Cesar Moncayo, Lukas Latzko, Johannes Laimer, Bernd Schöpf, Eberhard Steiner, Federica Fazzini, Helmut Klocker, Georg Schäfer |
| المصدر: | Cancers Volume 13 Issue 9 Cancers, Vol 13, Iss 2273, p 2273 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Mitochondrial DNA, Article, Correlation, 18[F]FDG-PET-CT, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Basal cell, mitochondrial DNA heteroplasmy, Survival analysis, RC254-282, PET-CT, business.industry, Hazard ratio, standardized uptake values, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Heteroplasmy, oral squamous cell carcinoma, 030104 developmental biology, 030220 oncology & carcinogenesis, Cohort, business |
| الوصف: | Simple Summary In this study, we evaluated the prognostic value of the positron emission tomography–computed tomography (PET-CT) imaging technique in patients with newly diagnosed oral squamous cell carcinomas. PET-CT is routinely used to detect and quantify metabolically active tissues such as tumors. By using receiver operating characteristic (ROC) analysis, we successfully determined an optimal cut-off value for patient stratification in order to predict clinical outcome in this population. Furthermore, other clinical variables and their impact on clinical outcome as well as PET-CT values were evaluated. We show that, based on the determined optimal cut-off value, PET-CT is a reliable and independent predictor for clinical outcome, even in a fully adjusted model. Finally, we analyzed mitochondrial DNA to evaluate if potentially deleterious mutations might be a potential cause of metabolic changes, leading to differences in PET-CT values and consequently, clinical outcome. Abstract Under aerobic conditions, some cancers switch to glycolysis to cover their energy requirements. Taking advantage of this process, functional imaging techniques such as PET-CT can be used to detect and assess tumorous tissues. The aim of this study was to investigate standardized uptake values and mitochondrial DNA mutations in oral squamous cell carcinoma. A cohort of 57 patients underwent 18[F]FDG-PET-CT and standardized uptake values were collected. In 15 patients, data on mitochondrial DNA mutations of the tumor were available. Kaplan–Meier curves were calculated, and correlation analyses as well as univariate Cox proportional hazard models were performed. Using ROC analysis to determine a statistical threshold for SUVmax in PET investigations, a cut-off value was determined at 9.765 MB/mL. Survival analysis for SUVmax in these groups showed a Hazard Ratio of 4 (95% CI 1.7–9) in the high SUVmax group with 5-year survival rates of 23.5% (p = 0.00042). For SUVmax and clinicopathological tumor features, significant correlations were found. A tendency towards higher mtDNA heteroplasmy levels in high SUVmax groups could be observed. We were able to confirm the prognostic value of SUVmax in OSCC, showing higher survival rates at lower SUVmax levels. Correlations between SUVmax and distinct tumor characteristics were highly significant, providing evidence that SUVmax may act as a reliable diagnostic parameter. Correlation analysis of mtDNA mutations suggests an influence on metabolic activity in OSCC. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6694 |
| DOI: | 10.3390/cancers13092273 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde0881eb6d55cd5efa877308a5822d5 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cde0881eb6d55cd5efa877308a5822d5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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| DOI: | 10.3390/cancers13092273 |