Cytosine arabinoside and mitoxantrone treatment of relapsed or refractory childhood leukemia: Initial response and relationship to multidrug resistance gene 1
| العنوان: | Cytosine arabinoside and mitoxantrone treatment of relapsed or refractory childhood leukemia: Initial response and relationship to multidrug resistance gene 1 |
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| المؤلفون: | Thomas A. Moulton, Michael White, Stuart H. Gold, Peter Waldron, James H. Feusner, Mitchell S. Cairo, Carl E. Krill, Eva Knoppell, Robert J. Wells, Lorrie F. Odom |
| المصدر: | Medical and Pediatric Oncology. 22:244-249 |
| بيانات النشر: | Wiley, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, medicine.medical_specialty, Adolescent, Childhood leukemia, medicine.drug_class, medicine.medical_treatment, Molecular Sequence Data, Drug Resistance, Gene Expression, Polymerase Chain Reaction, Antimetabolite, Gastroenterology, Recurrence, Internal medicine, Acute lymphocytic leukemia, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Child, Mitoxantrone, Chemotherapy, Leukemia, Membrane Glycoproteins, Base Sequence, business.industry, Remission Induction, Childhood Acute Myeloid Leukemia, Cytarabine, Infant, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Leukemia, Myeloid, Acute, Oncology, Child, Preschool, Pediatrics, Perinatology and Child Health, Immunology, Drug Evaluation, Female, Carrier Proteins, business, medicine.drug |
| الوصف: | The objective of this study was to determine the response rate and toxicity of high-dose cytosine arabinoside (AC) and mitoxantrone (M) in relapsed or refractory childhood acute myeloid leukemia (AML) and acute lymphocytic leukemia (ALL) and to correlate response with the expression of the multidrug resistance gene 1 (mdr1). Twenty-nine patients were treated with AC 1.0 g/m2 infused over 2 h every 12 h for eight doses (days 1-4) and M 12 mg/m2 infused over 1 h (days 3-6). Mdr1 expression was determined by a polymerase chain reaction (pcr) assay. Ten of 15 patients (67%) with AML obtained a complete remission (CR) of 3 to 30+ months duration. Eight of 14 (57%) ALL patients obtained a CR of 1 to 23+ months duration. The major toxicities were hematopoietic and infectious. Seventy-nine per cent of patients developed a documented infection during induction. Mdr1 did not correlate with a lower induction rate. This AC/M regimen is active in childhood AML and ALL. |
| تدمد: | 1096-911X 0098-1532 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf226292386f0141260e7c7f7571c9a https://doi.org/10.1002/mpo.2950220406 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....cdf226292386f0141260e7c7f7571c9a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1096911X 00981532 |
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