Insulin-like peptides signaling in Alzheimer's disease: on the road to alternative therapeutics
| العنوان: | Insulin-like peptides signaling in Alzheimer's disease: on the road to alternative therapeutics |
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| المؤلفون: | Angel Trueba-Saiz, Ignacio Torres Aleman |
| المساهمون: | Ministerio de Economía y Competitividad (España), Comunidad de Madrid, Fundación Centro de Investigación de Enfermedades Neurológicas |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | Elsevier BV, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, business.industry, Cognitive Neuroscience, Insulin, medicine.medical_treatment, Type 2 Diabetes Mellitus, Disease, Carbohydrate metabolism, medicine.disease, Bioinformatics, Pathogenesis, 03 medical and health sciences, Behavioral Neuroscience, Psychiatry and Mental health, 030104 developmental biology, 0302 clinical medicine, Insulin resistance, medicine, Dementia, business, Neuroscience, 030217 neurology & neurosurgery, Hormone |
| الوصف: | Several decades ago, the observation that Alzheimer's disease (AD) presents early disturbances in brain glucose metabolism prompted the notion of insulin dysregulation in this condition. Since then, abundant epidemiological evidence has associated AD to insulin resistance as in type 2 diabetes mellitus (T2DM). However, because the role of insulin in brain glucose handling is not clear, it cannot yet be firmly stated whether a T2DM-like condition in the brain might be cause or consequence of AD pathology. Additionally, it is becoming apparent that insulin and the closely related insulin-like peptides (i.e. IGF-I and IGF-II) modulate cognition in normal physiology, whereas robust evidence indicates central impairment of insulin/IGF-I signaling in AD patients. This may provide new leads into the pathology, even though there is still controversy on the role of these hormones in the pathogenesis of Alzheimer's dementia. At any rate, preliminary clinical trials using either intranasal insulin or IGF-I stimulating therapy show promising results. The present review summarizes major findings in the field during the last years, an intense period of research in this area. Our laboratory is funded by MINECO, Madrid local government and Ciberned. |
| تدمد: | 2352-1546 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce16b19c35c0e4d664f39f0379812c7a https://doi.org/10.1016/j.cobeha.2015.11.013 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ce16b19c35c0e4d664f39f0379812c7a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23521546 |
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