10-year results of On-X bileaflet mechanical heart valve in the aortic position: low target INR regimen in Japanese
| العنوان: | 10-year results of On-X bileaflet mechanical heart valve in the aortic position: low target INR regimen in Japanese |
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| المؤلفون: | Yosuke Miyamoto, Masahiko Ikebuchi, Ryuta Tai, Hideki Teshima, Hiroyuki Irie, Toshikazu Sano, Yusuke Kinugasa |
| المصدر: | General Thoracic and Cardiovascular Surgery. 65:435-440 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, Pulmonary and Respiratory Medicine, Aortic valve, medicine.medical_specialty, Heart Valve Diseases, 030204 cardiovascular system & hematology, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Japan, Aortic valve replacement, Internal medicine, Mitral valve, medicine, Humans, Sinus rhythm, Hospital Mortality, Survival rate, Stroke, Aged, Retrospective Studies, Aged, 80 and over, Heart Valve Prosthesis Implantation, business.industry, Incidence, Mortality rate, General Medicine, Middle Aged, medicine.disease, Surgery, Cardiac surgery, Survival Rate, medicine.anatomical_structure, 030228 respiratory system, Echocardiography, Aortic Valve, Heart Valve Prosthesis, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies, Forecasting |
| الوصف: | This study was designed to establish clinical outcomes after aortic valve replacement (AVR) with On-X bileaflet mechanical heart valve. Between 2006 and 2014, AVR was performed to 686 patients. Of them, 78 patients using On-X valve were enrolled. The mean age was 65 ± 11 years (ranged 33–85); 65% were men; and 81% were in sinus rhythm preoperatively. Calcific or degenerative tricuspid aortic valve was present in 73%. Concomitant procedures included coronary artery bypass grafting (22%), Bentall (8%), mitral valve procedure (3%) and other (9%). They postoperatively received lower dose warfarin [international normalized ratio (INR), 1.5–2.0] and 100 mg aspirin daily. The follow-up duration averaged 5 years (386.6 patient-years). The follow-up rate was 97.3%. In-hospital mortality rates were 3.8% (n = 3). Late mortality rates were 2.6% per patient-years (n = 10). Five-year Kaplan–Meier survival rates were 84%. Freedom from major adverse valve-related stroke and cerebral bleeding events was 93.3% (n = 5, 1.29% per patient-years) and 98.6% (n = 1, 0.26% per patient-years, mild subdural hematoma). The incidence of stroke was two patients of transient ischemic attack, two patients of paralytic event, one patient of asymptomatic stroke (self-interruption of anticoagulation). The median INR was 1.92 ± 0.53, ranged from 1.00 to 8.98 (n = 1181) and 51% of all measured INR values were in the therapeutic range of 1.5–2.0. AVR using On-X valve with low target INR regimen and low-dose aspirin resulted in a significantly low risk of bleeding. |
| تدمد: | 1863-6713 1863-6705 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce29c7dd1d159e5fcb6523fef1b7b98f https://doi.org/10.1007/s11748-017-0778-9 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....ce29c7dd1d159e5fcb6523fef1b7b98f |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 18636713 18636705 |
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