FUT8 is regulated by miR‐122‐5p and promotes malignancies in intrahepatic cholangiocarcinoma via PI3K/AKT signaling
| العنوان: | FUT8 is regulated by miR‐122‐5p and promotes malignancies in intrahepatic cholangiocarcinoma via PI3K/AKT signaling |
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| المؤلفون: | Fanghua, Chen, Yin, Li, Ling, Aye, Yingcheng, Wu, Liangqing, Dong, Zijian, Yang, Qiang, Gao, Shu, Zhang |
| المصدر: | Cellular Oncology. 46:79-91 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cancer Research, Oncology, Molecular Medicine, General Medicine |
| الوصف: | Intrahepatic cholangiocarcinoma (iCCA) is the second-most lethal primary liver cancer and its prognosis remains dismal. N-glycosylation, which is biosynthesized by a number of glycosyltransferases, plays an important role in a variety of biological processes and is associated with cancer development and progression.Based on our previous proteogenomic resources from an iCCA cohort of 262 patients, fucosyltransferases 8 (FUT8) showed significant prognosis relevance in iCCA. Tumor tissues from iCCA patients were used to evaluate the correlation between its expression and clinical information. Gain/loss-of-function experiments in iCCA cell lines were performed to elucidate the biological function of FUT8. In addition, its downstream pathways and post-transcriptional regulators were inferred and verified.Elevated FUT8 expression was clinically associated with worse overall survival in iCCA patients. Its overexpression promoted migration, invasion and proliferation ability of iCCA cells. In addition, miR-122-5p was found to act as a post-transcriptional regulator of FUT8 and proved to inhibit FUT8 expression and then suppress the proliferation and migration ability of iCCA cell lines. Furthermore, FUT8 was observed to promote iCCA development through PI3K/AKT signaling pathway.These findings demonstrated that FUT8, regulated by miR-122-5p, could be a tumor promoter of iCCA through PI3K/AKT signaling pathway. |
| تدمد: | 2211-3436 2211-3428 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2d1d1f72d9f1d9e8542dd0b00cd858 https://doi.org/10.1007/s13402-022-00736-y |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....ce2d1d1f72d9f1d9e8542dd0b00cd858 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 22113436 22113428 |
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