Genome sequence of the opportunistic human pathogen Magnusiomyces capitatus
| العنوان: | Genome sequence of the opportunistic human pathogen Magnusiomyces capitatus |
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| المؤلفون: | Vladislav Raclavský, Viktória Hodorová, Hana Lichancová, Jozef Nosek, B. Franz Lang, Lucia Zeiselova, Bronislava Brejová, Vladimíra Džugasová, Eva Hegedűsová, Martina Neboháčová, Andrej Baláž, Ľubomír Tomáška, Filip Brázdovič, Andrea Cillingová, Michaela Jakubkova, Tomáš Vinař |
| المصدر: | Current Genetics. 65:539-560 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Antifungal Agents, Virulence Factors, Human pathogen, Microbial Sensitivity Tests, Opportunistic Infections, Biology, Proteomics, Genome, Genetic recombination, 03 medical and health sciences, Genetics, Humans, Heterothallic, Gene, Phylogeny, 030304 developmental biology, Recombination, Genetic, 2. Zero hunger, Whole genome sequencing, 0303 health sciences, 030302 biochemistry & molecular biology, Computational Biology, Molecular Sequence Annotation, Genomics, General Medicine, Yeast, Phenotype, Mycoses, Multigene Family, Saccharomycetales, Genome, Fungal |
| الوصف: | The yeast Magnusiomyces capitatus is an opportunistic human pathogen causing rare yet severe infections, especially in patients with hematological malignancies. Here, we report the 20.2 megabase genome sequence of an environmental strain of this species as well as the genome sequences of eight additional isolates from human and animal sources providing an insight into intraspecies variation. The distribution of single-nucleotide variants is indicative of genetic recombination events, supporting evidence for sexual reproduction in this heterothallic yeast. Using RNAseq-aided annotation, we identified genes for 6518 proteins including several expanded families such as kexin proteases and Hsp70 molecular chaperones. Several of these families are potentially associated with the ability of M. capitatus to infect and colonize humans. For the purpose of comparative analysis, we also determined the genome sequence of a closely related yeast, Magnusiomyces ingens. The genome sequences of M. capitatus and M. ingens exhibit many distinct features and represent a basis for further comparative and functional studies. |
| تدمد: | 1432-0983 0172-8083 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce7e9d86ffc99bea161fe210f1e25605 https://doi.org/10.1007/s00294-018-0904-y |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....ce7e9d86ffc99bea161fe210f1e25605 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14320983 01728083 |
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