The Need to Study, Mimic, and Target Stem Cell Niches
| العنوان: | The Need to Study, Mimic, and Target Stem Cell Niches |
|---|---|
| المؤلفون: | Jeffrey M. Karp, Peter Anthony Jones, Jeroen Rouwkema, Ajaykumar Vishwakarma |
| المصدر: | Biology and Engineering of Stem Cell Niches, 3-13 STARTPAGE=3;ENDPAGE=13;TITLE=Biology and Engineering of Stem Cell Niches |
| بيانات النشر: | Elsevier, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Ecological niche, Microenvironment, Regeneration (biology), Niche, Extracellular matrix, Stem cell niche, Tissue repair, Biology, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Cell–cell interaction, Cell-cell interaction, Tissue regeneration, Cell-matrix interaction, Stem cell, 030217 neurology & neurosurgery |
| الوصف: | Despite important advances in tissue repair and regeneration over the past few decades, complete functional repair of damaged or diseased human tissues has remained elusive. Recent discoveries in stem cell niche molecular biology and biomaterials engineering may hold the key to true regeneration. Such efforts can be divided into three main approaches: (1) recruiting endogenous repair mechanisms in vivo, (2) administering cells in vivo, and (3) generating tissues/organs ex vivo. Central to these approaches is an understanding of stem cell niche molecules and signaling mechanisms, including cell–cell and cell–matrix interactions. To better study these mechanisms, scientific research has focused on the creation of a synthetic or artificial niche, a two- or three-dimensional microenvironment, constituted by the integration of mechanical and chemical cues such as extracellular matrix molecules and growth factors. This book is an attempt to comprehensively review our current understanding of the biology of the stem cell niche. It covers the elements that regulate stem cell behavior and highlights a variety of tools and techniques available in engineering and materials science for modeling synthetic stem cell niches in vivo or enhancing and directing stem cell fate in vitro. Finally, it describes stem cell niche bioengineering strategies and current advances in each tissue type. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb2bfcfdebde8d51e0289fcdf992833 https://doi.org/10.1016/b978-0-12-802734-9.00001-9 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....ceb2bfcfdebde8d51e0289fcdf992833 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |