Multifunctional RNA Nanoparticles
| العنوان: | Multifunctional RNA Nanoparticles |
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| المؤلفون: | Wade W. Grabow, Wah Chiu, Kirill A. Afonin, Mathias Viard, Jakob Reiser, Wojciech K. Kasprzak, Ravi V. Desai, Martin Panigaj, Eliahu Heldman, Luc Jaeger, Eric O. Freed, Alexey Y. Koyfman, Angelica N. Martins, Arti N. Santhanam, Bruce A. Shapiro |
| المصدر: | Nano Letters |
| بيانات النشر: | American Chemical Society (ACS), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Models, Molecular, RNA nanotechnology, Letter, Aptamer, aptamers, Mice, Nude, Nanoparticle, HIV Infections, Bioengineering, Nanotechnology, 02 engineering and technology, Genetic therapy, 03 medical and health sciences, RNA interference, RNA Aptamers, Cell Line, Tumor, Neoplasms, RNA nanoparticles, Animals, Humans, General Materials Science, RNA, Small Interfering, Gene, 030304 developmental biology, Mice nude, 0303 health sciences, Chemistry, Mechanical Engineering, RNA, Genetic Therapy, General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Cell biology, RNA−DNA hybrid reassociation, HIV-1, Nanoparticles, Female, 0210 nano-technology |
| الوصف: | Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNA-DNA hybrids aimed to conditionally activate multiple split functionalities inside cells. |
| تدمد: | 1530-6992 1530-6984 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec3f308e6e0f902bc623cd9d9238155 https://doi.org/10.1021/nl502385k |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cec3f308e6e0f902bc623cd9d9238155 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15306992 15306984 |
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