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Quantitative evaluation of emphysema for predicting immunotherapy response in patients with advanced non-small-cell lung cancer

التفاصيل البيبلوغرافية
العنوان: Quantitative evaluation of emphysema for predicting immunotherapy response in patients with advanced non-small-cell lung cancer
المؤلفون: Yoshimi Noda, Takayuki Shiroyama, Kentaro Masuhiro, Saori Amiya, Takatoshi Enomoto, Yuichi Adachi, Reina Hara, Takayuki Niitsu, Yujiro Naito, Kotaro Miyake, Shohei Koyama, Haruhiko Hirata, Izumi Nagatomo, Yoshito Takeda, Atsushi Kumanogoh
المصدر: Scientific reports. 12(1)
سنة النشر: 2021
مصطلحات موضوعية: Emphysema, Multidisciplinary, Lung Neoplasms, Pulmonary Emphysema, Carcinoma, Non-Small-Cell Lung, Humans, Immunologic Factors, Immunotherapy, Retrospective Studies
الوصف: The efficacy of immune checkpoint inhibitors (ICIs) in patients with advanced non-small-cell lung cancer (NSCLC) might depend on the presence of emphysema, but this association is not established. We aimed to investigate if quantitively and automatically measuring emphysema can predict the effect of ICIs. We retrospectively analyzed 56 patients with NSCLC who underwent immunotherapy at our hospital. We used the Goddard scoring system (GS) to evaluate the severity of emphysema on baseline CT scans using three-dimensional image analysis software. The emphysema group (GS ≥ 1) showed better progression-free survival (PFS) than the non-emphysema group (GS = 0) (6.5 vs. 2.3 months, respectively, p
تدمد: 2045-2322
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee295c2d07f4495349aa9de6848b684
https://pubmed.ncbi.nlm.nih.gov/35614345
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....cee295c2d07f4495349aa9de6848b684
قاعدة البيانات: OpenAIRE
الوصف
تدمد:20452322