Ultrasound combined with biochemical parameters can be used to differentiate parathyroid carcinoma from benign tumors in patients with primary hyperparathyroidism
| العنوان: | Ultrasound combined with biochemical parameters can be used to differentiate parathyroid carcinoma from benign tumors in patients with primary hyperparathyroidism |
|---|---|
| المؤلفون: | Yan-Ling Zheng, Xiaoyan Xie, Hui Huang, Wenjuan Tong, Mei-Qing Cheng, Jin-Yu Liang, Jiamin Pan, Manying Li |
| المصدر: | Clinical Hemorheology and Microcirculation. 76:351-359 |
| بيانات النشر: | IOS Press, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adenoma, Physiology, Urology, Parathyroid hormone, 030209 endocrinology & metabolism, Lesion, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), medicine, Humans, Aged, Retrospective Studies, Ultrasonography, Parathyroid adenoma, Aged, 80 and over, business.industry, Ultrasound, Hematology, Middle Aged, Hyperparathyroidism, Primary, medicine.disease, Parathyroid Neoplasms, Parathyroid carcinoma, 030220 oncology & carcinogenesis, Alkaline phosphatase, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Primary hyperparathyroidism |
| الوصف: | BACKGROUND: Primary hyperparathyroidism (PHPT) results from excessive secretion of parathyroid hormone from parathyroid tumors. Differentiating parathyroid tumors can be challenging before operation. OBJECTIVES: To differentiate parathyroid carcinoma from benign tumors in patients with PHPT by the application of ultrasound and biochemical parameters. METHODS: This study is a retrospective study. The study enrolled 17 patients with parathyroid carcinoma (PC) and 57 patients with parathyroid adenoma (PA), confirmed by postoperative pathology, between September 2010 and July 2017. This study retrospectively compared the ultrasonic features of the tumors included echotexture, maximum lesion diameter, shape, margin, blood flow inside the mass, intralesional calcifications, cysts in the mass, and biochemical parameters included serum calcium, phosphorus, parathyroid hormone (PTH), alkaline phosphatase (ALP) levels, gender distribution and age of patients between patients with PC and those with PA. RESULTS: In the US images, the two groups showed significant differences in heterogeneity, the appearance of a taller-than-wide shape, irregular or lobulated margins, and intralesional calcifications (p #x003E;> #x200A;0.05). The mean PTH levels were significantly different between the two groups (p #x003E;> #x200A;0.05). There were significant differences to distinguish PC from PA in calcifications in mass or/and taller-than-wide shape combine with PTH > #x003E;> #x200A;1000 pg/mL (p #x003E;> #x200A;0.05). CONCLUSION: Ultrasound features especially intralesional calcifications and taller-than-wide shape combine with an extremely high serum PTH (>1000 pg/mL) are helpful in differentiating between benign and parathyroid tumors in patients with PHPT. |
| تدمد: | 1875-8622 1386-0291 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee2eb2f2b11f7aec03948cb77ca3da8 https://doi.org/10.3233/ch-200846 |
| رقم الأكسشن: | edsair.doi.dedup.....cee2eb2f2b11f7aec03948cb77ca3da8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758622 13860291 |
|---|