The Transcription Factor Rbf1 Is the Master Regulator for b-Mating Type Controlled Pathogenic Development in Ustilago maydis
| العنوان: | The Transcription Factor Rbf1 Is the Master Regulator for b-Mating Type Controlled Pathogenic Development in Ustilago maydis |
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| المؤلفون: | Ramon Wahl, Volker Vincon, Chetsada Pothiratana, David Schuler, Miroslav Vranes, Mario Scherer, Jörg Kämper, Kai Heimel, Florian Finkernagel, Ignacio Flor-Parra |
| المساهمون: | Max Planck Society |
| المصدر: | PLoS Pathogens, Vol 6, Iss 8, p e1001035 (2010) PLoS Pathogens Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | Public Library of Science (PLoS), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | lcsh:Immunologic diseases. Allergy, Chromatin Immunoprecipitation, Ustilago, Genes, Fungal, Molecular Sequence Data, Immunology, Transcription factor complex, ComputingMilieux_LEGALASPECTSOFCOMPUTING, Cell Separation, Biology, Polymerase Chain Reaction, Microbiology, Cell Biology/Microbial Growth and Development, Gene Expression Regulation, Fungal, Virology, Gene expression, Genetics, Transcriptional regulation, lcsh:QH301-705.5, Molecular Biology, Gene, Transcription factor, Cell Biology/Gene Expression, Oligonucleotide Array Sequence Analysis, Zinc finger transcription factor, Regulation of gene expression, Base Sequence, Genetics and Genomics/Functional Genomics, Cell Cycle, Genetics and Genomics/Gene Expression, Microbiology/Plant-Biotic Interactions, Flow Cytometry, biology.organism_classification, lcsh:Biology (General), Cell Biology/Morphogenesis and Cell Biology, Parasitology, Microbiology/Cellular Microbiology and Pathogenesis, lcsh:RC581-607, Transcription Factors, Research Article |
| الوصف: | This is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al. In the phytopathogenic basidiomycete Ustilago maydis, sexual and pathogenic development are tightly connected and controlled by the heterodimeric bE/bW transcription factor complex encoded by the b-mating type locus. The formation of the active bE/bW heterodimer leads to the formation of filaments, induces a G2 cell cycle arrest, and triggers pathogenicity. Here, we identify a set of 345 bE/bW responsive genes which show altered expression during these developmental changes; several of these genes are associated with cell cycle coordination, morphogenesis and pathogenicity. 90% of the genes that show altered expression upon bE/bW-activation require the zinc finger transcription factor Rbf1, one of the few factors directly regulated by the bE/bW heterodimer. Rbf1 is a novel master regulator in a multilayered network of transcription factors that facilitates the complex regulatory traits of sexual and pathogenic development. We would like to thank R. Kahmann and the Max-Planck Institute for terrestrial Microbiology, Marburg, for generous support. |
| تدمد: | 1553-7374 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee3f51eaa285c81a468e7a1c6a0e812 https://doi.org/10.1371/journal.ppat.1001035 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cee3f51eaa285c81a468e7a1c6a0e812 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15537374 |
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