Pseudoboehmite as a drug delivery system for acyclovir
| العنوان: | Pseudoboehmite as a drug delivery system for acyclovir |
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| المؤلفون: | Maura Vincenza Rossi, Ayrton Bernussi, Mariana Oliva de Oliveira, Juliusz Warzywoda, Renato Meneghetti Peres, Antônio Hortêncio Munhoz Jr., Bruno Sarmento, Rene R. Oliveira, Jéssica Maiara Leme Sousa, Nelson Batista de Lima |
| المصدر: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
| بيانات النشر: | Nature Publishing Group UK, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cell Survival, Science, Acyclovir, Administration, Oral, Biological Availability, Nanogels, Aluminum Hydroxide, 02 engineering and technology, Pharmacology, medicine.disease_cause, Aluminium nitrate, Antiviral Agents, Article, Biomaterials, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Delivery Systems, medicine, Aluminum Oxide, Animals, Humans, Simplexvirus, Rats, Wistar, Multidisciplinary, Nanoscale materials, Pseudoboehmite, Herpes Simplex, 021001 nanoscience & nanotechnology, medicine.disease, Bioavailability, Rats, Cold sore, Ammonium hydroxide, Drug Liberation, Herpes simplex virus, chemistry, Drug delivery, Toxicity, Models, Animal, Medicine, Caco-2 Cells, 0210 nano-technology, 030217 neurology & neurosurgery |
| الوصف: | Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and it is indicated for the treatment and management of recurrent cold sores on the lips and face, genital herpes, among other diseases. The problem of the oral bioavailability of acyclovir is limited because of the low permeability across the gastrointestinal membrane. The use of nanoparticles of pseudoboehmite as a drug delivery system in vitro assays is a promising approach to further the permeability of acyclovir release. Here we report the synthesis of high purity pseudoboehmite from aluminium nitrate and ammonium hydroxide containing nanoparticles, using the sol–gel method, as a drug delivery system to improve the systemic bioavailability of acyclovir. The presence of pseudoboehmite nanoparticles were verified by infrared spectroscopy, transmission electron microscopy, and X-ray diffraction techniques. In vivo tests were performed with Wistar rats to compare the release of acyclovir, with and without the addition of pseudoboehmite. The administration of acyclovir with the addition of pseudoboehmite increased the drug content by 4.6 times in the plasma of Wistar rats after 4 h administration. We determined that the toxicity of pseudoboehmite is low up to 10 mg/mL, in gel and the dried pseudoboehmite nanoparticles. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceed2b2fb753666ca1230d5f96a6fcda http://europepmc.org/articles/PMC8322319 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ceed2b2fb753666ca1230d5f96a6fcda |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20452322 |
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