Neonatal lung immune responses show a shift of cytokines and transcription factors toward Th2 and a deficit in conventional and plasmacytoid dendritic cells
| العنوان: | Neonatal lung immune responses show a shift of cytokines and transcription factors toward Th2 and a deficit in conventional and plasmacytoid dendritic cells |
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| المؤلفون: | Aude Remot, Sabine Riffault, Xavier Le Roux, Hélène Kiefer-Biasizzo, Micheline Lagranderie, Gilles Marchal, Agnès Petit-Camurdan, Marie-Anne Nahori |
| المساهمون: | Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Institut National de la Recherche Agronomique (INRA), Institut Pasteur [Paris] (IP), INRA Animal Health division, region 'Ile de France', Medical Research Fund (FRM) FDT20060607329, INRA, Institut Pasteur [Paris] |
| المصدر: | European Journal of Immunology European Journal of Immunology, 2011, 41 (10), pp.2852-2861. ⟨10.1002/eji.201041224⟩ European Journal of Immunology, Wiley-VCH Verlag, 2011, 41, pp.2852-2861. ⟨10.1002/eji.201041224⟩ |
| بيانات النشر: | Wiley, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | DCs, Lung, Neonates, Th2, CD4-Positive T-Lymphocytes, CD3 Complex, [SDV]Life Sciences [q-bio], CD3, Immunology, GATA3 Transcription Factor, CD8-Positive T-Lymphocytes, Lymphocyte Activation, DCs, Mice, Th2, 03 medical and health sciences, Th2 Cells, 0302 clinical medicine, Immune system, Antigens, CD, medicine, Animals, Immunology and Allergy, Lymphocyte Count, Respiratory system, Lung, Lymph node, 030304 developmental biology, Mice, Inbred BALB C, 0303 health sciences, CD11b Antigen, biology, business.industry, Neonates, Dendritic Cells, T lymphocyte, respiratory system, Mycobacterium bovis, respiratory tract diseases, 3. Good health, medicine.anatomical_structure, Animals, Newborn, Integrin alpha M, biology.protein, Cytokines, business, Integrin alpha Chains, CD8, Transcription Factors, 030215 immunology |
| الوصف: | International audience; The high incidence of lung-damaging life-threatening respiratory infections in infants may be related to the immaturity of their immune systems. To determine whether lung immune features differ in early life compared with those in adulthood, whole lung as well as lung T lymphocyte and DC responses were investigated in BALB/c neonates versus adults. Higher expression of GATA-3 and rapid and sustained production of type 2 cytokines by lung explants after in vitro exposure to anti-CD3 was the hallmark of the neonatal period, suggestive of a Th2 bias. Neonatal lung GATA-3-producing cells were identified as CD31, CD4 and CD8 double-negative T lymphocytes, a subset found at a higher frequency in neonatal than adult lung. The neonatal lungs contained fewer conventional DCs, with a lower ratio of CD103 to CD11b DCs, and a much lower number of plasmacytoid DCs in comparison with adult lungs. Yet, when stimulated in vivo by BCG, neonatal lung DCs matured and primed adult naıve CD4 T cells toward Th1 as efficiently as adult BCG-primed lung DCs. Conversely,both adult and neonatal BCG-primed lung DCs induced a Th2 cytokine response from neonatal naıve lymph node Tcells, suggestive of anintrinsic feature of neonatal T lymphocytes. |
| تدمد: | 0014-2980 1521-4141 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0ceae9b8224a85d195b2882baed611 https://doi.org/10.1002/eji.201041224 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cf0ceae9b8224a85d195b2882baed611 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00142980 15214141 |
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