Alteration in gene expression profile of thymomas with or without myasthenia gravis linked with the nuclear factor‐kappaB/autoimmune regulator pathway to myasthenia gravis pathogenesis
| العنوان: | Alteration in gene expression profile of thymomas with or without myasthenia gravis linked with the nuclear factor‐kappaB/autoimmune regulator pathway to myasthenia gravis pathogenesis |
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| المؤلفون: | Chun-Yang Wang, Fan-Jie Meng, Zhi-Yu Guan, Shuo Wang, Jun Zhang, Feng Guo, Yi-Jie Yan |
| المصدر: | Thoracic Cancer Thoracic Cancer, Vol 10, Iss 3, Pp 564-570 (2019) |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Pulmonary and Respiratory Medicine, Candidate gene, Thymoma, Caveolin 3, Receptors, Nicotinic, lcsh:RC254-282, Autoimmune Diseases, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, Myasthenia Gravis, Gene expression, medicine, Humans, Regulation of gene expression, Receptors, Interleukin-7, pathway, business.industry, Neuron projection, NF-kappa B, Original Articles, General Medicine, Middle Aged, Striated muscle cell differentiation, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Microarray Analysis, medicine.disease, Autoimmune regulator, Myasthenia gravis, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, gene ontology, Original Article, Female, Transcriptome, business, microarray, Analysis, Thyroid Hormone Receptors alpha, Transcription Factors |
| الوصف: | Background To investigate the gene expression profile of a set of candidate genes for a better understanding of the molecular mechanism underlying the pathogenesis of thymoma with or without myasthenia gravis. Methods Thymoma patients and thymoma patients with myasthenia gravis were analyzed using microarray profiling to identify significant changes in gene expression of autoimmune regulator pathway genes including AIRE, IL-7R, CHRNA3, SYMD1, THRA, and CAV3. Results Across all of our samples, we found that 1484 mRNAs were upregulated and 770 were downregulated in thymoma patients compared with thymoma with myasthenia gravis patients. Gene ontology and pathway analysis revealed that a large number of genes participated in cellular functions for humoral immune response, sequence-specific DNA binding RNA polymerase II transcription factor activity, positive regulation of gene expression, regulation of neuron projection development, extracellular ligand-gated ion channel activity, positive regulation of striated muscle cell differentiation, and regulation of nuclear factor-kappaB import into the nucleus. Conclusion Our results revealed genetic differences between thymomas and myasthenia gravis, and identified the key candidate genes/pathways for molecular mechanism. |
| تدمد: | 1759-7714 1759-7706 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf12a43f98cd801f83bc44611e6c0117 https://doi.org/10.1111/1759-7714.12980 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cf12a43f98cd801f83bc44611e6c0117 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17597714 17597706 |
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