p38MAPK activation mediates tumor necrosis factor-α-induced apoptosis in glioma cells
| العنوان: | p38MAPK activation mediates tumor necrosis factor-α-induced apoptosis in glioma cells |
|---|---|
| المؤلفون: | Zhigang Wang, Yafei Zhang, Jianfei Gao, Bo Yang, Yong Zhao, Bi-Cheng Zhang, Jun Wang, Tingting Wu, Zhiguo Rao |
| المصدر: | Molecular Medicine Reports. 11:3101-3107 |
| بيانات النشر: | Spandidos Publications, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Cancer Research, CD30, p38 mitogen-activated protein kinases, Gene Expression, Apoptosis, Transfection, p38 Mitogen-Activated Protein Kinases, Biochemistry, Cell Line, Tumor, Glioma, Genetics, medicine, Animals, Protein kinase A, Molecular Biology, Cell Proliferation, Tumor Necrosis Factor-alpha, Chemistry, Cell Cycle, Cell cycle, medicine.disease, Rats, Cell biology, Enzyme Activation, Oncology, Cancer research, Molecular Medicine, Tumor necrosis factor alpha, Signal transduction |
| الوصف: | Gliomas are a type of heterogeneous primary central nervous system tumor, which arise from the glial cells; these types of tumor generally respond poorly to surgery, radiation and conventional chemotherapy. Tumor necrosis factor‑α (TNF‑α) has been suggested to produce an antitumor effect by binding to specific receptors on the tumor cell membrane to induce apoptosis. TNF‑α is known to activate a number of signaling pathways, including extracellular signal‑regulated protein kinase, c‑Jun N‑terminal kinase (JNK), p38 mitogen‑activated protein kinase (p38MAPK), nuclear factor‑κB and caspase cascades, depending on the cell type. However, the involvement of p38MAPK signaling in TNF‑α‑induced apoptosis in glioma cells remains unclear. In the current study, the role of p38MAPK in TNF‑α‑induced apoptosis in rat glioma C6 cells was investigated. TNF‑α was observed to induce cell apoptosis and the phosphorylation of p38MAPK in C6 cells. In addition, the inhibition of p38MAPK markedly reduced TNF‑α‑induced apoptosis, while JNK inhibition did not affect apoptosis. Furthermore, p38MAPK transfection altered the cell cycle of glioma cells and increased the rate of apoptosis. It also led to an increase in the level of soluble TNF‑α in the culture supernatant and membrane TNF receptor I levels in tumor cells. In conclusion, the results of the current study demonstrated that the activation of p38MAPK mediates TNF‑α‑induced apoptosis in glioma C6 cells, suggesting p38MAPK as a potential target for glioma therapy. |
| تدمد: | 1791-3004 1791-2997 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf23a045dbcbac6dc662a27dd7a586a6 https://doi.org/10.3892/mmr.2014.3002 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cf23a045dbcbac6dc662a27dd7a586a6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17913004 17912997 |
|---|