Prognostic of different glomerular filtration rate formulas in patients receiving percutaneous coronary intervention: insights from a multicenter observational cohort
| العنوان: | Prognostic of different glomerular filtration rate formulas in patients receiving percutaneous coronary intervention: insights from a multicenter observational cohort |
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| المؤلفون: | Pengcheng He, Yuanhui Liu, Wei Guo, Xue-Biao Wei, Jiyan Chen, Lei Jiang, Yan-Song Guo, Zhonghan Ni, Ning Tan, Wei Chen, Peng-Yuan Chen |
| المصدر: | BMC Cardiovascular Disorders, Vol 20, Iss 1, Pp 1-10 (2020) BMC Cardiovascular Disorders |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, China, lcsh:Diseases of the circulatory (Cardiovascular) system, Acute coronary syndrome, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Renal function, 030204 cardiovascular system & hematology, Kidney, Models, Biological, Risk Assessment, Decision Support Techniques, Percutaneous coronary intervention, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Internal medicine, Epidemiology, Non-ST elevation acute coronary syndrome, medicine, Humans, 030212 general & internal medicine, Acute Coronary Syndrome, Renal Insufficiency, Chronic, Non-ST Elevated Myocardial Infarction, Aged, Retrospective Studies, Receiver operating characteristic, business.industry, Middle Aged, Prognosis, medicine.disease, Treatment Outcome, lcsh:RC666-701, Cohort, Conventional PCI, Renal dysfunction, Female, Cardiology and Cardiovascular Medicine, business, Glomerular Filtration Rate, Research Article, Kidney disease |
| الوصف: | Background The relationships of renal dysfunction (RD) and chronic kidney disease (CKD) with prognosis have been well established among non-ST elevation acute coronary syndrome (NSTE-ACS) patients who receive percutaneous coronary intervention (PCI), but the efficacy of different estimated glomerular filtration rate (eGFR) formulas for predicting the prognosis is unknown. Methods The cohort originated from a retrospective data, which consecutively enrolled 8197 patients. The eGFR was calculated by the Cockcroft-Gault, Modification of Diet in Renal Disease (MDRD), CKD Epidemiology Collaboration-creatinine, CKD Epidemiology Collaboration-Cys-C, CKD Epidemiology Collaboration-Cys-C-creatinine and a modified abbreviated MDRD (c-aGFR) equations in Chinese CKD patients. Patients were excluded if the eGFR could not be obtained by one of the formulas. Patients were categorized as having normal renal function, mild RD, moderate RD, severe RD, or kidney failure to compare prognosis. The primary outcome was the in-hospital net adverse clinical events (NACE). The secondary outcomes were NACE and all-cause death during follow-up. Results In total, 2159 NSTE-ACS patients (age: 64.23 ± 10.25 years; males: 73.7%) were enrolled. 39 (1.8%) patients with in-hospital NACE were observed. During the 3.23 ± 1.55-year follow-up, 1.7% death and 4.2% NACE were observed in 1 year. The percentage of severe RD patients ranged from 15.4 to 39.2% according to different calculation formulas. A high prevalence of in-hospital NACE was observed in the severe RD groups (ranging from 8 to 14.3% for different formulas). Multiple regression analysis showed that a high eGFR is a protect factor against NACE and all-cause death regardless of the formula use. Receiver operating characteristic curves showed similar predictive performance of the c-aGFR when compared to other formulas (in-hospital NACE: AUC = 0.612, follow-up NACE: AUC = 0.622, and follow-up death: AUC = 0.711). Conclusions Severe RD results in a high prevalence of in-hospital NACE in NSTE-ACS patients after PCI regardless of the formulas use. Different formulas have a similar ability to predict in-hospital and long-term prognosis in NSTE-ACS patients. The c-aGFR formula is the simplest and a more convenient formula for use in practice. |
| تدمد: | 1471-2261 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2d6a765cbe0c10cfcae3c7cd98ce15 https://doi.org/10.1186/s12872-020-01621-y |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cf2d6a765cbe0c10cfcae3c7cd98ce15 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14712261 |
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