Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer
| العنوان: | Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer |
|---|---|
| المؤلفون: | Jung Lim Kim, Yoo Jin Na, Jun Young Heo, Seong Hye Park, Jeongsu Han, Dae Hee Lee, Sang Cheul Oh, Hye Kyeong Yun, Yoon A. Jeong, Soyeon Jeong, Hassan Ashktorab, Min Jee Jo, Han Do Kim, Sun Il Lee, Bo Ram Kim, Duane T. Smoot, Dae Yeong Kim, Bu Gyeom Kim, Dae Hyun Kim |
| المصدر: | Cell Death & Disease Cell Death and Disease, Vol 10, Iss 11, Pp 1-13 (2019) |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Cancer Research, Programmed cell death, Immunology, Mice, Nude, Apoptosis, X-Linked Inhibitor of Apoptosis Protein, Mitochondrion, digestive system, Article, Mitochondrial Proteins, Mice, Cellular and Molecular Neuroscience, Ubiquitin, Stomach Neoplasms, Biomarkers, Tumor, Tumor Cells, Cultured, medicine, Animals, Cannabidiol, Humans, Neoplasm Invasiveness, lcsh:QH573-671, Cell Proliferation, Mice, Inbred BALB C, biology, lcsh:Cytology, Chemistry, Cancer, Cell Biology, medicine.disease, Xenograft Model Antitumor Assays, digestive system diseases, XIAP, Gene Expression Regulation, Neoplastic, Cytosol, surgical procedures, operative, Cancer research, biology.protein, Female, biological phenomena, cell phenomena, and immunity, Apoptosis Regulatory Proteins, Gastric cancer, medicine.drug |
| الوصف: | According to recent studies, Cannabidiol (CBD), one of the main components of Cannabis sativa, has anticancer effects in several cancers. However, the exact mechanism of CBD action is not currently understood. Here, CBD promoted cell death in gastric cancer. We suggest that CBD induced apoptosis by suppressing X-linked inhibitor apoptosis (XIAP), a member of the IAP protein family. CBD reduced XIAP protein levels while increasing ubiquitination of XIAP. The expression of Smac, a known inhibitor of XIAP, was found to be elevated during CBD treatment. Moreover, CBD treatment increased the interaction between XIAP and Smac by increasing Smac release from mitochondria to the cytosol. CBD has also been shown to affect mitochondrial dysfunction. Taken together, these results suggest that CBD may have potential as a new therapeutic target in gastric cancer. |
| تدمد: | 2041-4889 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7a3276ba88ae640ab257ad4f400745 https://doi.org/10.1038/s41419-019-2001-7 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cf7a3276ba88ae640ab257ad4f400745 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20414889 |
|---|