Non-neutralizing antibodies increase endogenous circulating Ang1 levels
| العنوان: | Non-neutralizing antibodies increase endogenous circulating Ang1 levels |
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| المؤلفون: | David B. Hayes, Ryan M. Fryer, Rachel Kroe-Barrett, Sanjaya Singh, James D. Smith, Peng Sun, Margit MacDougall, Kristin Bovat, Joshuaine Toth, Kavita Jerath, Chao Zheng, Tammy Bigwarfe |
| المصدر: | mAbs |
| بيانات النشر: | Informa UK Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, non-neutralizing antibody, YTE, Immunology, Endogeny, 030204 cardiovascular system & hematology, Pharmacology, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Report, Angiopoietin-1, Animals, Humans, Immunology and Allergy, Receptor, biology, Chemistry, Antibodies, Monoclonal, Ligand (biochemistry), Receptor, TIE-2, Angiopoietin receptor, Immunoglobulin Fc Fragments, Ang1, Macaca fascicularis, Tie2, HEK293 Cells, 030104 developmental biology, Immunoglobulin G, Mutation, biology.protein, half-life extension, Antibody, Protein Binding |
| الوصف: | Ang1 is a soluble ligand to receptor Tie2, and increasing the circulating Ang1 level may improve vascular stabilization under certain disease conditions. Here, we found that the circulating Ang1 level was significantly increased in cynomolgus monkeys treated with non-neutralizing anti-Ang1 antibodies. Improving the antibodies’ pharmacokinetic properties by IgG Fc mutations further increased the circulating Ang1 level. However, the mutations decreased the thermal stability of the molecules, which may limit their use as therapeutic antibodies. Nevertheless, we showed that non-neutralizing antibodies may have therapeutic potential by increasing the level of a target molecule in the circulation. |
| تدمد: | 1942-0870 1942-0862 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8f100ac1c7308df1c03be75ebc9bb4 https://doi.org/10.1080/19420862.2018.1521130 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cf8f100ac1c7308df1c03be75ebc9bb4 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 19420870 19420862 |
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