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Xiehui Chen,1 Weichao Huang,2 Lingyue Zhao,3 Yichong Li,2 Lili Wang,2 Fanrui Mo,4 Wenqin Guo2 1Department of Cardiology, Shenzhen Longhua District Central Hospital, Shenzhen, Peopleâs Republic of China; 2Department of Cardiology, Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, Peopleâs Republic of China; 3Department of Ambulatory Surgery, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, Peopleâs Republic of China; 4Department of Cardiology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Peopleâs Republic of ChinaCorrespondence: Lingyue ZhaoDepartment of Ambulatory Surgery, Huazhong University of Science and Technology Union Shenzhen Hospital, Nanshan District, Shenzhen, Peopleâs Republic of ChinaTel/Fax +86 755-26553111Email z07198102755@163.comFanrui MoDepartment of Cardiology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Peopleâs Republic of ChinaTel +86 772-3815284Fax +86 772-3815384Email 9313902@qq.comPurpose: The aim of this study was to assess the value of the eosinophil/monocyte ratio (EMR) for predicting the prognosis of decompensated heart failure (HF).Patients and Methods: This was a retrospective cohort study. We included adults (⥠18 years old) diagnosed with decompensated HF for whom EMR data were available. The patients were divided into three groups according to EMR tertiles (T1 [EMR⤠0.15], T2 [0.15 0.32]). The primary endpoint was the composite outcome of cardiovascular death or HF rehospitalization.Results: Initially, the records of 2264 patients with decompensated HF were screened; 1883 of these patients had EMR data and were therefore included in the study. There were 627 patients in the T1 group, 628 in the T2 group, and 628 in the T3 group. The risk of cardiovascular death or HF rehospitalization was significantly different among the three groups (Log rank test, P=0.007). Compared with the T3 group, both the T1 group (hazard ratio [HR]: 1.50, 95% confidence interval [CI]: 1.16â 1.94, P=0.002) and the T2 group (HR: 1.34, 95% CI: 1.03â 1.74, P=0.030) had significantly higher rates of cardiovascular death or HF rehospitalization. A Cochran-Armitage test for trend showed a positive correlation between the EMR and the composite outcome of cardiovascular death or HF. There was a significant difference between the three groups in terms of cardiovascular death (Log rank test, P< 0.001) and HF rehospitalization (Log rank test, P=0.03).Conclusion: The EMR is positively correlated with the risk of cardiovascular death or HF rehospitalization in patients with decompensated HF. Specifically, the lower the EMR, the higher the risk of cardiovascular death or HF rehospitalization.Keywords: decompensated heart failure, eosinophil/monocyte ratio, prognosis, cardiovascular death, heart failure rehospitalization |
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