Unraveling the genetics of complex diseases: Susceptibility genes for rheumatoid arthritis and psoriasis
العنوان: | Unraveling the genetics of complex diseases: Susceptibility genes for rheumatoid arthritis and psoriasis |
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المؤلفون: | Yonghong Li, Ann B. Begovich |
المصدر: | Seminars in Immunology. 21:318-327 |
بيانات النشر: | Elsevier BV, 2009. |
سنة النشر: | 2009 |
مصطلحات موضوعية: | musculoskeletal diseases, Genetics, Immunology, Arthritis, Genome-wide association study, Human leukocyte antigen, Biology, medicine.disease_cause, medicine.disease, TNFAIP3, Autoimmunity, Arthritis, Rheumatoid, PTPN22, Psoriasis, medicine, Animals, Humans, Immunology and Allergy, Genetic Predisposition to Disease, Allelic heterogeneity, skin and connective tissue diseases, Genome-Wide Association Study |
الوصف: | Talk of numerous genetic risk factors for rheumatoid arthritis (RA) and psoriasis has been percolating for years, but with the exception of the human leukocyte antigen (HLA) region, none have been definitively identified. Recently the results of multiple, well powered, genetic case-control studies have begun to appear providing convincing statistical evidence for at least ten non-HLA related risk genes or loci (C5/TRAF1, CD40, CTLA4, KIF5A/PIP4K2C, MMEL1/TNFRSF14, PADI4, PRKCQ, PTPN22, STAT4, and TNFAIP3/OLIG3) for RA and six (IL12B, IL13, IL23R, STAT2/IL23A, TNFAIP3, and TNIP1) for psoriasis. These initial, novel findings are beginning to shed light on the molecular pathways pertinent to the individual diseases and highlight the pleiotropic effects of several risk factors as well as the allelic heterogeneity underlying susceptibility to these and other autoimmune diseases. |
تدمد: | 1044-5323 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d002ab8f62292de8e2279ae424142d18 https://doi.org/10.1016/j.smim.2009.04.002 |
حقوق: | CLOSED |
رقم الأكسشن: | edsair.doi.dedup.....d002ab8f62292de8e2279ae424142d18 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 10445323 |
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