Long-term efficacy and safety of fostemsavir among subgroups of heavily treatment-experienced adults with HIV-1
| العنوان: | Long-term efficacy and safety of fostemsavir among subgroups of heavily treatment-experienced adults with HIV-1 |
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| المؤلفون: | Max Lataillade, Marcelo Martins, Peter Ackerman, Isabel Cassetti, Michael J. Kozal, Eduardo Sprinz, Jean-Michel Molina, Gilles Pialoux, Antonella Castagna, Moti Ramgopal, Gulam H Latiff, Amy Pierce, Princy Kumar, Adrian Streinu-Cercel, Shiven Chabria, Judith A. Aberg, Sandra Treviño-Pérez, Marcia Wang, Melanie Thompson, Cyril Llamoso |
| المساهمون: | Ackerman, P., Thompson, M., Molina, J. -M., Aberg, J., Cassetti, I., Kozal, M., Castagna, A., Martins, M., Ramgopal, M., Sprinz, E., Trevino-Perez, S., Streinu-Cercel, A., Latiff, G. H., Pialoux, G., Kumar, P. N., Wang, M., Chabria, S., Pierce, A., Llamoso, C., Lataillade, M. |
| المصدر: | AIDS (London, England) Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, heavily treatment-experienced, Antirretrovirais, optimized background therapy, Human immunodeficiency virus (HIV), Phases of clinical research, HIV Infections, medicine.disease_cause, Piperazines, 0302 clinical medicine, Immunology and Allergy, Medicine, 030212 general & internal medicine, Resistência a medicamentos, education.field_of_study, Multiple antiretroviral drug resistance, Viral Load, Clinical Science, Organophosphates, antiretroviral agents, Infectious Diseases, Fostemsavir, Treatment Outcome, Cohort, Viral load, Adult, medicine.medical_specialty, Anti-HIV Agents, Immunology, Population, Optimized background therapy, Treatment experienced, 03 medical and health sciences, susceptibility score, Internal medicine, Humans, Adverse effect, education, fostemsavir, attachment inhibitor, business.industry, multiple antiretroviral drug resistance, Heavily treatment-experienced, Antiretroviral agents, CD4 Lymphocyte Count, 030104 developmental biology, Fármacos anti-HIV, HIV-1, Attachment inhibitor, business, Susceptibility score |
| الوصف: | OBJECTIVES: The aim of this study was to understand how demographic and treatment-related factors impact responses to fostemsavir-based regimens. DESIGN: BRIGHTE is an ongoing phase 3 study evaluating twice-daily fostemsavir 600 mg and optimized background therapy (OBT) in heavily treatment-experienced individuals failing antiretroviral therapy with limited treatment options (Randomized Cohort 1-2 and Nonrandomized Cohort 0 fully active antiretroviral classes). METHODS: Virologic response rates (HIV-1 RNA |
| وصف الملف: | application/pdf |
| تدمد: | 1473-5571 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00eba98b1c2d2424aa242dd17969d5d https://pubmed.ncbi.nlm.nih.gov/33946085 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d00eba98b1c2d2424aa242dd17969d5d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14735571 |
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