Enzymatic modular synthesis and microarray assay of poly-N-acetyllactosamine derivatives
| العنوان: | Enzymatic modular synthesis and microarray assay of poly-N-acetyllactosamine derivatives |
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| المؤلفون: | Fei Liu, Lei Li, He Zhu, Congcong Chen, Madhusudhan Reddy Gadi, Peixue Ling, Shuaishuai Wang, Hongzhi Cao, Chang-Cheng Liu, Fengshan Wang |
| المصدر: | Chemical Communications. 56:7549-7552 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Glycan, Glycosylation, Microarray, 010402 general chemistry, 01 natural sciences, DNA-binding protein, Griffonia, Catalysis, Poly-N-acetyllactosamine, Ascomycota, Bacterial Proteins, Polysaccharides, Lectins, Materials Chemistry, Humans, Maackia, Avidity, Fucosylation, Binding affinities, chemistry.chemical_classification, Bacteria, Molecular Structure, biology, 010405 organic chemistry, Metals and Alloys, Glycosyltransferases, General Chemistry, Microarray Analysis, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, carbohydrates (lipids), Hemagglutinins, Enzyme, Carbohydrate Sequence, chemistry, Biochemistry, Ceramics and Composites, biology.protein, Plant Lectins, E-Selectin |
| الوصف: | A facile enzymatic modular assembly strategy for the preparative-scale synthesis of poly-N-acetyllactosamine (poly-LacNAc) glycans with varied lengths and designed sialylation and/or fucosylation patterns is described. These glycans were printed as a microarray to investigate their interactions with a panel of glycan binding proteins (GBPs). Binding affinities revealed that the avidity of GBPs could be largely affected by the length and the patterns of sialylation and fucosylation. |
| تدمد: | 1364-548X 1359-7345 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d059695d168aa71dd2ddb15efb4cddf3 https://doi.org/10.1039/d0cc03268a |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....d059695d168aa71dd2ddb15efb4cddf3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1364548X 13597345 |
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